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n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea.
Br J Nutr. 2008 Sep; 100(3):609-14.BJ

Abstract

n-3 and Trans fatty acids are considered to be the important modifiable factors of the metabolic syndrome. The purpose of this study was to test the hypothesis that lower Omega-3 fatty acids and/or higher trans fatty acids of erythrocytes (RBC) are associated with the risk of the metabolic syndrome. Forty-four patients with the metabolic syndrome, defined by three or more risk factors of the modified Adult Treatment Panel III criteria, and eighty-eight age- and sex-matched controls with less than three risk factors were recruited for the study. The mean age was 54.5 (sem 0.8) years and 45 % of subjects were female. Trans fatty acids of RBC were higher in patients than controls (0.82 (sem 0.04) v. 0.73 (sem 0.03) %; P = 0.043), while their Omega-3 indexes, the sum of EPA and DHA in RBC, did not significantly differ (11.78 (sem 0.04) v. 12.39 (sem 0.02) %). Multivariable-adjusted regression analysis showed positive association between trans fatty acid and risk of the metabolic syndrome (OR 7.13; 95 % CI 1.53, 33.27; P = 0.013). Fasting serum insulin (7.9 (sem 0.7) v. 4.9 (sem 0.3) muU/ml; P < 0.001) and high sensitivity C-reactive protein (18 (sem 3) v. 11 (sem 17) mg/l; P = 0.042) were also higher in patients than controls. There were significant positive relationships between trans fatty acids and waist circumference, and between trans fatty acids and BMI. The results suggested that RBC trans fatty acids might be a predictor of increased risk for the metabolic syndrome, but n-3 fatty acids were not in this population.

Authors+Show Affiliations

Department of Food and Nutrition, Hanyang University, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18304391

Citation

Lee, Eunjeong, et al. "N-3 Polyunsaturated Fatty Acids and Trans Fatty Acids in Patients With the Metabolic Syndrome: a Case-control Study in Korea." The British Journal of Nutrition, vol. 100, no. 3, 2008, pp. 609-14.
Lee E, Lee S, Park Y. N-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea. Br J Nutr. 2008;100(3):609-14.
Lee, E., Lee, S., & Park, Y. (2008). N-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea. The British Journal of Nutrition, 100(3), 609-14. https://doi.org/10.1017/S0007114508925435
Lee E, Lee S, Park Y. N-3 Polyunsaturated Fatty Acids and Trans Fatty Acids in Patients With the Metabolic Syndrome: a Case-control Study in Korea. Br J Nutr. 2008;100(3):609-14. PubMed PMID: 18304391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea. AU - Lee,Eunjeong, AU - Lee,Sangyeoup, AU - Park,Yongsoon, Y1 - 2008/02/28/ PY - 2008/2/29/pubmed PY - 2009/2/27/medline PY - 2008/2/29/entrez SP - 609 EP - 14 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 100 IS - 3 N2 - n-3 and Trans fatty acids are considered to be the important modifiable factors of the metabolic syndrome. The purpose of this study was to test the hypothesis that lower Omega-3 fatty acids and/or higher trans fatty acids of erythrocytes (RBC) are associated with the risk of the metabolic syndrome. Forty-four patients with the metabolic syndrome, defined by three or more risk factors of the modified Adult Treatment Panel III criteria, and eighty-eight age- and sex-matched controls with less than three risk factors were recruited for the study. The mean age was 54.5 (sem 0.8) years and 45 % of subjects were female. Trans fatty acids of RBC were higher in patients than controls (0.82 (sem 0.04) v. 0.73 (sem 0.03) %; P = 0.043), while their Omega-3 indexes, the sum of EPA and DHA in RBC, did not significantly differ (11.78 (sem 0.04) v. 12.39 (sem 0.02) %). Multivariable-adjusted regression analysis showed positive association between trans fatty acid and risk of the metabolic syndrome (OR 7.13; 95 % CI 1.53, 33.27; P = 0.013). Fasting serum insulin (7.9 (sem 0.7) v. 4.9 (sem 0.3) muU/ml; P < 0.001) and high sensitivity C-reactive protein (18 (sem 3) v. 11 (sem 17) mg/l; P = 0.042) were also higher in patients than controls. There were significant positive relationships between trans fatty acids and waist circumference, and between trans fatty acids and BMI. The results suggested that RBC trans fatty acids might be a predictor of increased risk for the metabolic syndrome, but n-3 fatty acids were not in this population. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18304391/n_3_Polyunsaturated_fatty_acids_and_trans_fatty_acids_in_patients_with_the_metabolic_syndrome:_a_case_control_study_in_Korea_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508925435/type/journal_article DB - PRIME DP - Unbound Medicine ER -