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The management of portal hypertension: rational basis, available treatments and future options.
J Hepatol. 2008; 48 Suppl 1:S68-92.JH

Abstract

Variceal bleeding is the last step in a chain of events initiated by an increase in portal pressure, followed by the development and progressive dilation of varices until these finally rupture and bleed. This sequence of events might be prevented - and reversed - by achieving a sufficient decrease in portal pressure. A different approach is the use of local endoscopic treatments at the varices. This article reviews the rationale for the management of patients with cirrhosis and portal hypertension, the current recommendations for the prevention and treatment of variceal bleeding, and outlines the unsolved issues and the perspectives for the future opened by new research developments.

Authors+Show Affiliations

Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Hospital Clínic, C.Villarroel 170, 08036 Barcelona, Spain. jbosch@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18304681

Citation

Bosch, Jaime, et al. "The Management of Portal Hypertension: Rational Basis, Available Treatments and Future Options." Journal of Hepatology, vol. 48 Suppl 1, 2008, pp. S68-92.
Bosch J, Berzigotti A, Garcia-Pagan JC, et al. The management of portal hypertension: rational basis, available treatments and future options. J Hepatol. 2008;48 Suppl 1:S68-92.
Bosch, J., Berzigotti, A., Garcia-Pagan, J. C., & Abraldes, J. G. (2008). The management of portal hypertension: rational basis, available treatments and future options. Journal of Hepatology, 48 Suppl 1, S68-92. https://doi.org/10.1016/j.jhep.2008.01.021
Bosch J, et al. The Management of Portal Hypertension: Rational Basis, Available Treatments and Future Options. J Hepatol. 2008;48 Suppl 1:S68-92. PubMed PMID: 18304681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The management of portal hypertension: rational basis, available treatments and future options. AU - Bosch,Jaime, AU - Berzigotti,Annalisa, AU - Garcia-Pagan,Juan Carlos, AU - Abraldes,Juan G, Y1 - 2008/02/12/ PY - 2008/2/29/pubmed PY - 2008/6/18/medline PY - 2008/2/29/entrez SP - S68 EP - 92 JF - Journal of hepatology JO - J Hepatol VL - 48 Suppl 1 N2 - Variceal bleeding is the last step in a chain of events initiated by an increase in portal pressure, followed by the development and progressive dilation of varices until these finally rupture and bleed. This sequence of events might be prevented - and reversed - by achieving a sufficient decrease in portal pressure. A different approach is the use of local endoscopic treatments at the varices. This article reviews the rationale for the management of patients with cirrhosis and portal hypertension, the current recommendations for the prevention and treatment of variceal bleeding, and outlines the unsolved issues and the perspectives for the future opened by new research developments. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/18304681/The_management_of_portal_hypertension:_rational_basis_available_treatments_and_future_options_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(08)00077-9 DB - PRIME DP - Unbound Medicine ER -