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Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide.
J Ethnopharmacol. 2008 Apr 17; 117(1):170-4.JE

Abstract

AIM OF THE STUDY

Cissus sicyoides L. is a medicinal plant popularly known in Brazil against various diseases and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer.

MATERIALS AND METHODS

The methanolic extract obtained from the leaves of Cissus sicyoides (Cc) was evaluated for the ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% EtOH, absolute ethanol, piroxicam and pylorus ligature) in rodents. We also evaluated microcirculation, antioxidant action and participation of NO (nitric oxide) and sulfhydryls (SH) groups in the Cc gastroprotective action.

RESULTS

Administration of Cc significantly reduced gastric lesions induced by different ulcerogenic agents in rodents. This extract administered by oral route significantly increased gastric volume without exerting antisecretory effect. The Cc effect involved an increase of the defense mechanism of the gastrointestinal mucosa such as NO and SH groups that prevent and attenuate the ulcer process. The Cc also has antioxidant property against oxidative stress but does not modify microcirculation response in gastric mucosa.

CONCLUSIONS

These results confirmed the traditional use of Cissus sicyoides for the treatment of gastric ulcer.

Authors+Show Affiliations

Physiology Department, Biosciences Institute, CP 510,UNESP-São Paulo State University, 18618-000 Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18304768

Citation

de Paula Ferreira, Mariana, et al. "Gastroprotective Effect of Cissus Sicyoides (Vitaceae): Involvement of Microcirculation, Endogenous Sulfhydryls and Nitric Oxide." Journal of Ethnopharmacology, vol. 117, no. 1, 2008, pp. 170-4.
de Paula Ferreira M, Nishijima CM, Seito LN, et al. Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide. J Ethnopharmacol. 2008;117(1):170-4.
de Paula Ferreira, M., Nishijima, C. M., Seito, L. N., Dokkedal, A. L., Lopes-Ferreira, M., Di Stasi, L. C., Vilegas, W., & Hiruma-Lima, C. A. (2008). Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide. Journal of Ethnopharmacology, 117(1), 170-4. https://doi.org/10.1016/j.jep.2008.01.008
de Paula Ferreira M, et al. Gastroprotective Effect of Cissus Sicyoides (Vitaceae): Involvement of Microcirculation, Endogenous Sulfhydryls and Nitric Oxide. J Ethnopharmacol. 2008 Apr 17;117(1):170-4. PubMed PMID: 18304768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide. AU - de Paula Ferreira,Mariana, AU - Nishijima,Catarine Massucato, AU - Seito,Leonardo Norobu, AU - Dokkedal,Anne Ligia, AU - Lopes-Ferreira,Mônica, AU - Di Stasi,Luiz Cláudio, AU - Vilegas,Wagner, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2008/01/19/ PY - 2007/11/14/received PY - 2008/01/04/revised PY - 2008/01/12/accepted PY - 2008/2/29/pubmed PY - 2008/7/3/medline PY - 2008/2/29/entrez SP - 170 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 117 IS - 1 N2 - AIM OF THE STUDY: Cissus sicyoides L. is a medicinal plant popularly known in Brazil against various diseases and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer. MATERIALS AND METHODS: The methanolic extract obtained from the leaves of Cissus sicyoides (Cc) was evaluated for the ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% EtOH, absolute ethanol, piroxicam and pylorus ligature) in rodents. We also evaluated microcirculation, antioxidant action and participation of NO (nitric oxide) and sulfhydryls (SH) groups in the Cc gastroprotective action. RESULTS: Administration of Cc significantly reduced gastric lesions induced by different ulcerogenic agents in rodents. This extract administered by oral route significantly increased gastric volume without exerting antisecretory effect. The Cc effect involved an increase of the defense mechanism of the gastrointestinal mucosa such as NO and SH groups that prevent and attenuate the ulcer process. The Cc also has antioxidant property against oxidative stress but does not modify microcirculation response in gastric mucosa. CONCLUSIONS: These results confirmed the traditional use of Cissus sicyoides for the treatment of gastric ulcer. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18304768/Gastroprotective_effect_of_Cissus_sicyoides__Vitaceae_:_involvement_of_microcirculation_endogenous_sulfhydryls_and_nitric_oxide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00036-6 DB - PRIME DP - Unbound Medicine ER -