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Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results.
Clin Vaccine Immunol. 2008 Apr; 15(4):726-8.CV

Abstract

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Authors+Show Affiliations

MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241, USA. legan@miravistalabs.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18305106

Citation

Egan, Lindsey, et al. "Detection of Histoplasma Capsulatum Antigenuria By Ultrafiltration of Samples With False-negative Results." Clinical and Vaccine Immunology : CVI, vol. 15, no. 4, 2008, pp. 726-8.
Egan L, Connolly PA, Fuller D, et al. Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results. Clin Vaccine Immunol. 2008;15(4):726-8.
Egan, L., Connolly, P. A., Fuller, D., Davis, T. E., Witt, J., Knox, K. S., Hage, C. A., & Wheat, L. J. (2008). Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results. Clinical and Vaccine Immunology : CVI, 15(4), 726-8. https://doi.org/10.1128/CVI.00493-07
Egan L, et al. Detection of Histoplasma Capsulatum Antigenuria By Ultrafiltration of Samples With False-negative Results. Clin Vaccine Immunol. 2008;15(4):726-8. PubMed PMID: 18305106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results. AU - Egan,Lindsey, AU - Connolly,Patricia A, AU - Fuller,Deanna, AU - Davis,Thomas E, AU - Witt,John,3rd AU - Knox,Kenneth S, AU - Hage,Chadi A, AU - Wheat,L Joseph, Y1 - 2008/02/27/ PY - 2008/2/29/pubmed PY - 2008/10/17/medline PY - 2008/2/29/entrez SP - 726 EP - 8 JF - Clinical and vaccine immunology : CVI JO - Clin Vaccine Immunol VL - 15 IS - 4 N2 - Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/18305106/Detection_of_Histoplasma_capsulatum_antigenuria_by_ultrafiltration_of_samples_with_false_negative_results_ L2 - http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=18305106 DB - PRIME DP - Unbound Medicine ER -