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Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice.
Am J Chin Med. 2008; 36(1):149-57.AJ

Abstract

Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18306458

Citation

Huang, Cai Guo, et al. "Hypouricemic Effects of Phenylpropanoid Glycosides Acteoside of Scrophularia Ningpoensis On Serum Uric Acid Levels in Potassium Oxonate-pretreated Mice." The American Journal of Chinese Medicine, vol. 36, no. 1, 2008, pp. 149-57.
Huang CG, Shang YJ, Zhang J, et al. Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. Am J Chin Med. 2008;36(1):149-57.
Huang, C. G., Shang, Y. J., Zhang, J., Zhang, J. R., Li, W. J., & Jiao, B. H. (2008). Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. The American Journal of Chinese Medicine, 36(1), 149-57.
Huang CG, et al. Hypouricemic Effects of Phenylpropanoid Glycosides Acteoside of Scrophularia Ningpoensis On Serum Uric Acid Levels in Potassium Oxonate-pretreated Mice. Am J Chin Med. 2008;36(1):149-57. PubMed PMID: 18306458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice. AU - Huang,Cai Guo, AU - Shang,Yan Jun, AU - Zhang,Jun, AU - Zhang,Jian Rong, AU - Li,Wen Jie, AU - Jiao,Bin Hua, PY - 2008/2/29/pubmed PY - 2008/8/12/medline PY - 2008/2/29/entrez SP - 149 EP - 57 JF - The American journal of Chinese medicine JO - Am. J. Chin. Med. VL - 36 IS - 1 N2 - Phenylpropanoid glycoside acteoside was extracted from the traditional Chinese medicine Scrophularia ningpoenis Hemsl. In the present study, we investigated the effects of acteoside administration on serum uric acid levels in mice rendered hyperuricemic with the uricase inhibitor potassium oxonate. When administered orally for 3 days at doses of 50, 100 and 150 mg/kg, acteoside reduced serum uric acid levels by 15.2, 23.8 and 33.1%, respectively, relative to vehicle-treated hyperuricemic mice. Importantly, in non-hyperuricemic mice, the serum uric acid levels were not affected by acetoside treatment. Acteoside also inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity at all three doses. These results suggest that the hypouricemic action of acteoside may be attributable to its inhibition of XDH/XO activity. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/18306458/Hypouricemic_effects_of_phenylpropanoid_glycosides_acteoside_of_Scrophularia_ningpoensis_on_serum_uric_acid_levels_in_potassium_oxonate_pretreated_Mice_ L2 - https://www.worldscientific.com/doi/full/10.1142/S0192415X08005667?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -