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Haematological study in sickle cell homozygous and heterozygous children in the age group 0-6 years.
Indian J Pathol Microbiol. 2007 Oct; 50(4):901-4.IJ

Abstract

Sickle cell anaemia is a common and widespread haemoglobinopathy with large clinical heterogeneity. The present study, was undertaken to determine seven different haematological parameters (Haemoglobin percent, RBC count, PCV, MCV MCH, MCHC, Reticulocyte count) on total 102 heterozygous (SA) and homozygous (SS) sickle cell children under six years of age. In addition, fetal haemoglobin (HbF) level was estimated in SS children and correlated with clinical status, gender and ethnic background. Mean HbF was 16.79%. Higher HbF level was associated with less severe clinical feature. HbF was not influenced by gender and ethnic background. In homozygous children mean values of MCV, MCH, MCHC were decreased while reticulocyte count was increased as compared to control (AA) children and (SA) children (P < 0.05) We conclude that, in sickle cell disease, HbF was a good prognostic indicator. Higher HbF level along with microcytic hyopochromic indices and lower MCHC was found to be a feature of the study population.

Authors+Show Affiliations

Department of Pathology, IGMC, Nagpur. drvaishaliw@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18306601

Citation

Walke, Vaishali A., and M S. Walde. "Haematological Study in Sickle Cell Homozygous and Heterozygous Children in the Age Group 0-6 Years." Indian Journal of Pathology & Microbiology, vol. 50, no. 4, 2007, pp. 901-4.
Walke VA, Walde MS. Haematological study in sickle cell homozygous and heterozygous children in the age group 0-6 years. Indian J Pathol Microbiol. 2007;50(4):901-4.
Walke, V. A., & Walde, M. S. (2007). Haematological study in sickle cell homozygous and heterozygous children in the age group 0-6 years. Indian Journal of Pathology & Microbiology, 50(4), 901-4.
Walke VA, Walde MS. Haematological Study in Sickle Cell Homozygous and Heterozygous Children in the Age Group 0-6 Years. Indian J Pathol Microbiol. 2007;50(4):901-4. PubMed PMID: 18306601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haematological study in sickle cell homozygous and heterozygous children in the age group 0-6 years. AU - Walke,Vaishali A, AU - Walde,M S, PY - 2008/3/1/pubmed PY - 2008/3/26/medline PY - 2008/3/1/entrez SP - 901 EP - 4 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 50 IS - 4 N2 - Sickle cell anaemia is a common and widespread haemoglobinopathy with large clinical heterogeneity. The present study, was undertaken to determine seven different haematological parameters (Haemoglobin percent, RBC count, PCV, MCV MCH, MCHC, Reticulocyte count) on total 102 heterozygous (SA) and homozygous (SS) sickle cell children under six years of age. In addition, fetal haemoglobin (HbF) level was estimated in SS children and correlated with clinical status, gender and ethnic background. Mean HbF was 16.79%. Higher HbF level was associated with less severe clinical feature. HbF was not influenced by gender and ethnic background. In homozygous children mean values of MCV, MCH, MCHC were decreased while reticulocyte count was increased as compared to control (AA) children and (SA) children (P < 0.05) We conclude that, in sickle cell disease, HbF was a good prognostic indicator. Higher HbF level along with microcytic hyopochromic indices and lower MCHC was found to be a feature of the study population. SN - 0377-4929 UR - https://www.unboundmedicine.com/medline/citation/18306601/Haematological_study_in_sickle_cell_homozygous_and_heterozygous_children_in_the_age_group_0_6_years_ DB - PRIME DP - Unbound Medicine ER -