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The concept of neurogenic inflammation.
BJU Int. 2008 Mar; 101 Suppl 3:2-6.BI

Abstract

Neurogenic inflammatory responses have recently been linked to both acute and chronic pathological conditions in the urinary tract. Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons and the subsequent release of inflammatory neuropeptides, including substance P and calcitonin gene-related peptide. The reduction of neurogenic inflammatory responses may be key in the mode of action of the adrenergic alpha(1)-adrenoceptor antagonists used to treat lower urinary tract symptoms (LUTS). Indeed, the alpha(1)-adrenoceptor antagonist alfuzosin inhibits expression of the oncogene c-fos- a marker of nociceptive pathway activation - evoked by cyclophosphamide in rats. Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals. Involvement of the TRP cation channel, subfamily A, member 1 (TRPA1) has also been reported in models of neurogenic inflammation and nociception promoted by the cyclophosphamide metabolite, acrolein. Blockade by alfuzosin demonstrates the beneficial effects of alpha(1)-adrenoceptor antagonists on neurogenic inflammation via the transient receptor potential family of ionic channels. Consequently, these drugs may have an important role in reducing LUTS.

Authors+Show Affiliations

Department of Critical Care Medicine and Surgery, Clinical Pharmacology Unit, University of Florence, Florence, Italy. pierangelo.geppetti@unifi.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18307678

Citation

Geppetti, Pierangelo, et al. "The Concept of Neurogenic Inflammation." BJU International, vol. 101 Suppl 3, 2008, pp. 2-6.
Geppetti P, Nassini R, Materazzi S, et al. The concept of neurogenic inflammation. BJU Int. 2008;101 Suppl 3:2-6.
Geppetti, P., Nassini, R., Materazzi, S., & Benemei, S. (2008). The concept of neurogenic inflammation. BJU International, 101 Suppl 3, 2-6. https://doi.org/10.1111/j.1464-410X.2008.07493.x
Geppetti P, et al. The Concept of Neurogenic Inflammation. BJU Int. 2008;101 Suppl 3:2-6. PubMed PMID: 18307678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The concept of neurogenic inflammation. AU - Geppetti,Pierangelo, AU - Nassini,Romina, AU - Materazzi,Serena, AU - Benemei,Silvia, PY - 2008/3/1/pubmed PY - 2008/3/29/medline PY - 2008/3/1/entrez SP - 2 EP - 6 JF - BJU international JO - BJU Int. VL - 101 Suppl 3 N2 - Neurogenic inflammatory responses have recently been linked to both acute and chronic pathological conditions in the urinary tract. Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons and the subsequent release of inflammatory neuropeptides, including substance P and calcitonin gene-related peptide. The reduction of neurogenic inflammatory responses may be key in the mode of action of the adrenergic alpha(1)-adrenoceptor antagonists used to treat lower urinary tract symptoms (LUTS). Indeed, the alpha(1)-adrenoceptor antagonist alfuzosin inhibits expression of the oncogene c-fos- a marker of nociceptive pathway activation - evoked by cyclophosphamide in rats. Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals. Involvement of the TRP cation channel, subfamily A, member 1 (TRPA1) has also been reported in models of neurogenic inflammation and nociception promoted by the cyclophosphamide metabolite, acrolein. Blockade by alfuzosin demonstrates the beneficial effects of alpha(1)-adrenoceptor antagonists on neurogenic inflammation via the transient receptor potential family of ionic channels. Consequently, these drugs may have an important role in reducing LUTS. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/18307678/The_concept_of_neurogenic_inflammation_ L2 - https://doi.org/10.1111/j.1464-410X.2008.07493.x DB - PRIME DP - Unbound Medicine ER -