Tags

Type your tag names separated by a space and hit enter

Risk, determinants, and outcome implications of progression of mitral regurgitation after diagnosis of mitral valve prolapse in a single community.
Am J Cardiol. 2008 Mar 01; 101(5):662-7.AJ

Abstract

To analyze the evolution of mitral regurgitation (MR) after the diagnosis of mitral valve prolapse in community patients, 285 residents of Olmsted County, Minnesota, diagnosed with mitral valve prolapse without severe MR were studied. MR grade was assessed at diagnosis and at follow-up 1,663 +/- 1,079 days later using Doppler echocardiography. The progression of MR was defined as an increase of > or =1 MR grade. The patients' mean age was 56 +/- 22 years, 57% were women, and the mean ejection fraction was 60 +/- 9%. Between diagnostic and follow-up echocardiography, 108 patients showed progression of MR, 39 of whom had progression > or =1 grade. The mean overall MR grade increased from 0.4 +/- 0.7 to 0.9 +/- 1.1 (p <0.01). The progression of MR was observed in all subsets, irrespective of age, gender, prolapse localization, leaflet thickening, and initial MR grade. However, multivariate analysis identified age (p <0.01) and initial MR grade (p = 0.01) as independent predictors of progression. In addition, MR progression was associated with greater left atrial enlargement (p <0.001), ventricular dilatation (p = 0.02 for increase in end-diastolic and end-systolic diameters), and a worse outcome (adjusted p = 0.001). In conclusion, in patients with mitral valve prolapse, MR progression was observed over time in all clinical and anatomic subsets and was associated with more severe ventricular and atrial remodeling and worse outcome.

Authors+Show Affiliations

Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA. jfavierinos@ap-hm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18308017

Citation

Avierinos, Jean-Francois, et al. "Risk, Determinants, and Outcome Implications of Progression of Mitral Regurgitation After Diagnosis of Mitral Valve Prolapse in a Single Community." The American Journal of Cardiology, vol. 101, no. 5, 2008, pp. 662-7.
Avierinos JF, Detaint D, Messika-Zeitoun D, et al. Risk, determinants, and outcome implications of progression of mitral regurgitation after diagnosis of mitral valve prolapse in a single community. Am J Cardiol. 2008;101(5):662-7.
Avierinos, J. F., Detaint, D., Messika-Zeitoun, D., Mohty, D., & Enriquez-Sarano, M. (2008). Risk, determinants, and outcome implications of progression of mitral regurgitation after diagnosis of mitral valve prolapse in a single community. The American Journal of Cardiology, 101(5), 662-7. https://doi.org/10.1016/j.amjcard.2007.10.029
Avierinos JF, et al. Risk, Determinants, and Outcome Implications of Progression of Mitral Regurgitation After Diagnosis of Mitral Valve Prolapse in a Single Community. Am J Cardiol. 2008 Mar 1;101(5):662-7. PubMed PMID: 18308017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk, determinants, and outcome implications of progression of mitral regurgitation after diagnosis of mitral valve prolapse in a single community. AU - Avierinos,Jean-Francois, AU - Detaint,Delphine, AU - Messika-Zeitoun,David, AU - Mohty,Dania, AU - Enriquez-Sarano,Maurice, Y1 - 2008/01/16/ PY - 2007/04/23/received PY - 2007/10/05/revised PY - 2007/10/05/accepted PY - 2008/3/1/pubmed PY - 2008/4/11/medline PY - 2008/3/1/entrez SP - 662 EP - 7 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 101 IS - 5 N2 - To analyze the evolution of mitral regurgitation (MR) after the diagnosis of mitral valve prolapse in community patients, 285 residents of Olmsted County, Minnesota, diagnosed with mitral valve prolapse without severe MR were studied. MR grade was assessed at diagnosis and at follow-up 1,663 +/- 1,079 days later using Doppler echocardiography. The progression of MR was defined as an increase of > or =1 MR grade. The patients' mean age was 56 +/- 22 years, 57% were women, and the mean ejection fraction was 60 +/- 9%. Between diagnostic and follow-up echocardiography, 108 patients showed progression of MR, 39 of whom had progression > or =1 grade. The mean overall MR grade increased from 0.4 +/- 0.7 to 0.9 +/- 1.1 (p <0.01). The progression of MR was observed in all subsets, irrespective of age, gender, prolapse localization, leaflet thickening, and initial MR grade. However, multivariate analysis identified age (p <0.01) and initial MR grade (p = 0.01) as independent predictors of progression. In addition, MR progression was associated with greater left atrial enlargement (p <0.001), ventricular dilatation (p = 0.02 for increase in end-diastolic and end-systolic diameters), and a worse outcome (adjusted p = 0.001). In conclusion, in patients with mitral valve prolapse, MR progression was observed over time in all clinical and anatomic subsets and was associated with more severe ventricular and atrial remodeling and worse outcome. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/18308017/Risk_determinants_and_outcome_implications_of_progression_of_mitral_regurgitation_after_diagnosis_of_mitral_valve_prolapse_in_a_single_community_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)02141-8 DB - PRIME DP - Unbound Medicine ER -