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Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin.
Life Sci. 2008 Mar 26; 82(13-14):741-51.LS

Abstract

Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic-pituitary-adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CMS-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects, and might help to elucidate its mechanisms of action that are involved in normalization of stress-induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity.

Authors+Show Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18308340

Citation

Yi, Li-Tao, et al. "Antidepressant-like Behavioral and Neurochemical Effects of the Citrus-associated Chemical Apigenin." Life Sciences, vol. 82, no. 13-14, 2008, pp. 741-51.
Yi LT, Li JM, Li YC, et al. Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin. Life Sci. 2008;82(13-14):741-51.
Yi, L. T., Li, J. M., Li, Y. C., Pan, Y., Xu, Q., & Kong, L. D. (2008). Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin. Life Sciences, 82(13-14), 741-51. https://doi.org/10.1016/j.lfs.2008.01.007
Yi LT, et al. Antidepressant-like Behavioral and Neurochemical Effects of the Citrus-associated Chemical Apigenin. Life Sci. 2008 Mar 26;82(13-14):741-51. PubMed PMID: 18308340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin. AU - Yi,Li-Tao, AU - Li,Jian-Mei, AU - Li,Yu-Cheng, AU - Pan,Ying, AU - Xu,Qun, AU - Kong,Ling-Dong, Y1 - 2008/01/30/ PY - 2007/07/14/received PY - 2008/01/12/revised PY - 2008/01/16/accepted PY - 2008/3/1/pubmed PY - 2008/6/10/medline PY - 2008/3/1/entrez SP - 741 EP - 51 JF - Life sciences JO - Life Sci VL - 82 IS - 13-14 N2 - Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic-pituitary-adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CMS-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects, and might help to elucidate its mechanisms of action that are involved in normalization of stress-induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/18308340/Antidepressant_like_behavioral_and_neurochemical_effects_of_the_citrus_associated_chemical_apigenin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(08)00037-4 DB - PRIME DP - Unbound Medicine ER -