Tags

Type your tag names separated by a space and hit enter

Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test.
J Psychopharmacol. 2008 Aug; 22(6):691-6.JP

Abstract

The present study investigated the effects of neurosteroids dehydroepiandrosterone sulfate (DHEAS) or pregnenolone sulfate (PS) on the tail-suspension test (TST) of depression in mice, and also the possible involvement of sigma (sigma) receptors. Immobility time in the TST was measured for a total period of 6 min. DHEAS (10 and 40 mg/kg, s.c.) or PS (40 mg/kg, s.c.) significantly reduced the immobility period without accompanying changes in the locomotor activity in mice. The effect on behavioural despair by DHEAS (10 and 40 mg/kg, s.c.) and PS (40 mg/kg, s.c.) was blocked by BD 1047 (1 mg/kg, s.c.), a novel sigma1-receptor antagonist, progesterone (10 mg/kg, s.c.), a sigma-receptor antagonistic neurosteroid or rimcazole (5 mg/kg, s.c.), another sigma1-receptor antagonistic property, respectively. The treatments and their combination did not alter the motor activity in mice. These data suggested a role for the central sigma receptors particularly sigma-1 (sigma1) receptors in the anti-depressant-like effects of neurosteroids.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18308813

Citation

Dhir, A, and Sk Kulkarni. "Involvement of Sigma (sigma1) Receptors in Modulating the Anti-depressant Effect of Neurosteroids (dehydroepiandrosterone or Pregnenolone) in Mouse Tail-suspension Test." Journal of Psychopharmacology (Oxford, England), vol. 22, no. 6, 2008, pp. 691-6.
Dhir A, Kulkarni S. Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test. J Psychopharmacol. 2008;22(6):691-6.
Dhir, A., & Kulkarni, S. (2008). Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test. Journal of Psychopharmacology (Oxford, England), 22(6), 691-6. https://doi.org/10.1177/0269881107082771
Dhir A, Kulkarni S. Involvement of Sigma (sigma1) Receptors in Modulating the Anti-depressant Effect of Neurosteroids (dehydroepiandrosterone or Pregnenolone) in Mouse Tail-suspension Test. J Psychopharmacol. 2008;22(6):691-6. PubMed PMID: 18308813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test. AU - Dhir,A, AU - Kulkarni,Sk, Y1 - 2008/02/28/ PY - 2008/3/1/pubmed PY - 2008/12/31/medline PY - 2008/3/1/entrez SP - 691 EP - 6 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 22 IS - 6 N2 - The present study investigated the effects of neurosteroids dehydroepiandrosterone sulfate (DHEAS) or pregnenolone sulfate (PS) on the tail-suspension test (TST) of depression in mice, and also the possible involvement of sigma (sigma) receptors. Immobility time in the TST was measured for a total period of 6 min. DHEAS (10 and 40 mg/kg, s.c.) or PS (40 mg/kg, s.c.) significantly reduced the immobility period without accompanying changes in the locomotor activity in mice. The effect on behavioural despair by DHEAS (10 and 40 mg/kg, s.c.) and PS (40 mg/kg, s.c.) was blocked by BD 1047 (1 mg/kg, s.c.), a novel sigma1-receptor antagonist, progesterone (10 mg/kg, s.c.), a sigma-receptor antagonistic neurosteroid or rimcazole (5 mg/kg, s.c.), another sigma1-receptor antagonistic property, respectively. The treatments and their combination did not alter the motor activity in mice. These data suggested a role for the central sigma receptors particularly sigma-1 (sigma1) receptors in the anti-depressant-like effects of neurosteroids. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/18308813/Involvement_of_sigma__sigma1__receptors_in_modulating_the_anti_depressant_effect_of_neurosteroids__dehydroepiandrosterone_or_pregnenolone__in_mouse_tail_suspension_test_ L2 - https://journals.sagepub.com/doi/10.1177/0269881107082771?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -