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Intrauterine risk factors for precocious atherosclerosis.

Abstract

Evidence from noninvasive ultrasound studies of the neonatal aorta and fetal and early childhood postmortem studies indicates that impaired fetal growth, in utero exposure to maternal hypercholesterolemia, and diabetic macrosomia may all be important risk factors for vascular changes consistent with the earliest physical signs of atherosclerosis. Although the exact mechanisms that underlie these associations remain unclear, animal models have suggested that the use of antioxidant, lipid-lowering, and other innovative therapies may counteract the impact of these intrauterine risk factors for cardiovascular disease. This review summarizes the current evidence for intrauterine factors that have a direct impact on atherosclerosis and provides potential treatment and prevention strategies.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Human Nutrition Research Centre, Université Claude Bernard, Lyon, France. michael.skilton@baker.edu.au

    Source

    Pediatrics 121:3 2008 Mar pg 570-4

    MeSH

    Age of Onset
    Atherosclerosis
    Female
    Fetal Growth Retardation
    Fetal Macrosomia
    Humans
    Hypercholesterolemia
    Incidence
    Infant, Newborn
    Male
    Maternal-Fetal Exchange
    Predictive Value of Tests
    Pregnancy
    Pregnancy Complications
    Prognosis
    Risk Assessment
    Sensitivity and Specificity
    Time Factors
    Ultrasonography, Prenatal

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18310207

    Citation

    Skilton, Michael R.. "Intrauterine Risk Factors for Precocious Atherosclerosis." Pediatrics, vol. 121, no. 3, 2008, pp. 570-4.
    Skilton MR. Intrauterine risk factors for precocious atherosclerosis. Pediatrics. 2008;121(3):570-4.
    Skilton, M. R. (2008). Intrauterine risk factors for precocious atherosclerosis. Pediatrics, 121(3), pp. 570-4. doi:10.1542/peds.2007-1801.
    Skilton MR. Intrauterine Risk Factors for Precocious Atherosclerosis. Pediatrics. 2008;121(3):570-4. PubMed PMID: 18310207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intrauterine risk factors for precocious atherosclerosis. A1 - Skilton,Michael R, PY - 2008/3/4/pubmed PY - 2008/3/21/medline PY - 2008/3/4/entrez SP - 570 EP - 4 JF - Pediatrics JO - Pediatrics VL - 121 IS - 3 N2 - Evidence from noninvasive ultrasound studies of the neonatal aorta and fetal and early childhood postmortem studies indicates that impaired fetal growth, in utero exposure to maternal hypercholesterolemia, and diabetic macrosomia may all be important risk factors for vascular changes consistent with the earliest physical signs of atherosclerosis. Although the exact mechanisms that underlie these associations remain unclear, animal models have suggested that the use of antioxidant, lipid-lowering, and other innovative therapies may counteract the impact of these intrauterine risk factors for cardiovascular disease. This review summarizes the current evidence for intrauterine factors that have a direct impact on atherosclerosis and provides potential treatment and prevention strategies. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/18310207/full_citation L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=18310207 DB - PRIME DP - Unbound Medicine ER -