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A modern hypothesis: The distinct pathologies of dementia associated with Parkinson's disease versus Alzheimer's disease.
Dement Geriatr Cogn Disord. 2008; 25(4):301-8.DG

Abstract

BACKGROUND/AIMS

Parkinson's disease dementia (PDD) is common, but its neuropathological basis has been controversial. The aim of this review was to survey the recent literature on the pathology of PDD and compare the pathology of PDD to that of Alzheimer's disease (AD).

METHODS

A literature search was performed to identify relevant research published since 2001.

RESULTS

There is widespread Lewy body pathology in the neocortex and subcortical regions in PDD, and Lewy neurites in the CA2 region of the hippocampus that correlate with cognitive decline. Genetic forms of PD, which frequently lead to dementia, are associated with deposition of alpha-synuclein; PDD is not related to the apolipoprotein E epsilon 4 genotype. Compared with AD, central cholinergic deficits occur earlier, are greater and more widespread in PDD, but PDD can occur without the abundant senile plaques and neurofibrillary tangles indicative of AD.

CONCLUSION

Epidemiological investigations, neuroimaging, as well as genetic and neuropathological studies increasingly support PDD as distinct from AD.

Authors+Show Affiliations

Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. mfarlow@iupui.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18311077

Citation

Farlow, Martin R., and Jeffrey Cummings. "A Modern Hypothesis: the Distinct Pathologies of Dementia Associated With Parkinson's Disease Versus Alzheimer's Disease." Dementia and Geriatric Cognitive Disorders, vol. 25, no. 4, 2008, pp. 301-8.
Farlow MR, Cummings J. A modern hypothesis: The distinct pathologies of dementia associated with Parkinson's disease versus Alzheimer's disease. Dement Geriatr Cogn Disord. 2008;25(4):301-8.
Farlow, M. R., & Cummings, J. (2008). A modern hypothesis: The distinct pathologies of dementia associated with Parkinson's disease versus Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 25(4), 301-8. https://doi.org/10.1159/000119104
Farlow MR, Cummings J. A Modern Hypothesis: the Distinct Pathologies of Dementia Associated With Parkinson's Disease Versus Alzheimer's Disease. Dement Geriatr Cogn Disord. 2008;25(4):301-8. PubMed PMID: 18311077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A modern hypothesis: The distinct pathologies of dementia associated with Parkinson's disease versus Alzheimer's disease. AU - Farlow,Martin R, AU - Cummings,Jeffrey, Y1 - 2008/03/03/ PY - 2007/12/01/accepted PY - 2008/3/4/pubmed PY - 2008/6/18/medline PY - 2008/3/4/entrez SP - 301 EP - 8 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 25 IS - 4 N2 - BACKGROUND/AIMS: Parkinson's disease dementia (PDD) is common, but its neuropathological basis has been controversial. The aim of this review was to survey the recent literature on the pathology of PDD and compare the pathology of PDD to that of Alzheimer's disease (AD). METHODS: A literature search was performed to identify relevant research published since 2001. RESULTS: There is widespread Lewy body pathology in the neocortex and subcortical regions in PDD, and Lewy neurites in the CA2 region of the hippocampus that correlate with cognitive decline. Genetic forms of PD, which frequently lead to dementia, are associated with deposition of alpha-synuclein; PDD is not related to the apolipoprotein E epsilon 4 genotype. Compared with AD, central cholinergic deficits occur earlier, are greater and more widespread in PDD, but PDD can occur without the abundant senile plaques and neurofibrillary tangles indicative of AD. CONCLUSION: Epidemiological investigations, neuroimaging, as well as genetic and neuropathological studies increasingly support PDD as distinct from AD. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18311077/A_modern_hypothesis:_The_distinct_pathologies_of_dementia_associated_with_Parkinson's_disease_versus_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -