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Severe labetalol overdose in an 8-month-old infant.
Paediatr Anaesth. 2008 May; 18(5):435-8.PA

Abstract

We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta. Labetalol, both alpha and beta adrenergic blocking agent was used for treating postoperative hypertension. By mistake, the patient was given an extremely high dose of labetalol intravenously (17.2 mg.kg(-1)). Remarkably, the medication error had a surprisingly limited clinical effect on the infant who survived the incident. We discuss the pharmacokinetic, pharmocodynamic and possible explanations for this fortunate turn of events.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Thorsteinsson A
Department of Anesthesiology and Intensive Care Medicine, Landspitali University Hospital, Reykjavik, Iceland. adalbjn@landspitali.is
Johannesdottir A
No affiliation info available
Eiríksson H
No affiliation info available
Helgason H
No affiliation info available

MeSH

Antihypertensive AgentsAortic CoarctationFemaleHumansHypertensionInfantLabetalolMedication ErrorsPostoperative Complications

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18312512

Citation

Thorsteinsson, Adalbjörn, et al. "Severe Labetalol Overdose in an 8-month-old Infant." Paediatric Anaesthesia, vol. 18, no. 5, 2008, pp. 435-8.
Thorsteinsson A, Johannesdottir A, Eiríksson H, et al. Severe labetalol overdose in an 8-month-old infant. Paediatr Anaesth. 2008;18(5):435-8.
Thorsteinsson, A., Johannesdottir, A., Eiríksson, H., & Helgason, H. (2008). Severe labetalol overdose in an 8-month-old infant. Paediatric Anaesthesia, 18(5), 435-8. https://doi.org/10.1111/j.1460-9592.2008.02501.x
Thorsteinsson A, et al. Severe Labetalol Overdose in an 8-month-old Infant. Paediatr Anaesth. 2008;18(5):435-8. PubMed PMID: 18312512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe labetalol overdose in an 8-month-old infant. AU - Thorsteinsson,Adalbjörn, AU - Johannesdottir,Astridur, AU - Eiríksson,Herbert, AU - Helgason,Hródmar, Y1 - 2008/02/28/ PY - 2008/3/4/pubmed PY - 2008/4/18/medline PY - 2008/3/4/entrez SP - 435 EP - 8 JF - Paediatric anaesthesia JO - Paediatr Anaesth VL - 18 IS - 5 N2 - We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta. Labetalol, both alpha and beta adrenergic blocking agent was used for treating postoperative hypertension. By mistake, the patient was given an extremely high dose of labetalol intravenously (17.2 mg.kg(-1)). Remarkably, the medication error had a surprisingly limited clinical effect on the infant who survived the incident. We discuss the pharmacokinetic, pharmocodynamic and possible explanations for this fortunate turn of events. SN - 1460-9592 UR - https://www.unboundmedicine.com/medline/citation/18312512/Severe_labetalol_overdose_in_an_8_month_old_infant_ DB - PRIME DP - Unbound Medicine ER -