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Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease.
Nutrition 2008; 24(3):239-44N

Abstract

OBJECTIVE

Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD.

METHODS

This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured.

RESULTS

Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (beta = -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35).

CONCLUSION

Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double.

Authors+Show Affiliations

Critical Care and Respiratory Therapy, Taichung Veterans General Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18312786

Citation

Cheng, Chien-Hsiung, et al. "Plasma Pyridoxal 5'-phosphate and High-sensitivity C-reactive Protein Are Independently Associated With an Increased Risk of Coronary Artery Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 3, 2008, pp. 239-44.
Cheng CH, Lin PT, Liaw YP, et al. Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease. Nutrition. 2008;24(3):239-44.
Cheng, C. H., Lin, P. T., Liaw, Y. P., Ho, C. C., Tsai, T. P., Chou, M. C., & Huang, Y. C. (2008). Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease. Nutrition (Burbank, Los Angeles County, Calif.), 24(3), pp. 239-44. doi:10.1016/j.nut.2007.12.003.
Cheng CH, et al. Plasma Pyridoxal 5'-phosphate and High-sensitivity C-reactive Protein Are Independently Associated With an Increased Risk of Coronary Artery Disease. Nutrition. 2008;24(3):239-44. PubMed PMID: 18312786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease. AU - Cheng,Chien-Hsiung, AU - Lin,Ping-Ting, AU - Liaw,Yung-Po, AU - Ho,Chien-Chang, AU - Tsai,Tsung-Po, AU - Chou,Ming-Chih, AU - Huang,Yi-Chia, PY - 2007/09/10/received PY - 2007/11/09/revised PY - 2007/12/09/accepted PY - 2008/3/4/pubmed PY - 2008/5/28/medline PY - 2008/3/4/entrez SP - 239 EP - 44 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 3 N2 - OBJECTIVE: Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD. METHODS: This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured. RESULTS: Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (beta = -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35). CONCLUSION: Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18312786/Plasma_pyridoxal_5'_phosphate_and_high_sensitivity_C_reactive_protein_are_independently_associated_with_an_increased_risk_of_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(07)00358-9 DB - PRIME DP - Unbound Medicine ER -