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Prevalence and risk factors of PAD among patients with elevated ABI.
Eur J Vasc Endovasc Surg. 2008 Jun; 35(6):709-14.EJ

Abstract

OBJECTIVES

To assess the prevalence and clinical significance of elevated ankle-brachial index (ABI) in patients referred to vascular consultation.

DESIGN

Retrospective clinical study.

MATERIAL AND METHODS

In 1,762 patients referred with a suspicion of peripheral arterial disease (PAD), ABI and toe brachial index (TBI) were measured by photoplethysmography. ABI>/=1.3 was considered falsely elevated and TBI<0.60 was the diagnostic criterion for PAD.

RESULTS

The prevalence of elevated ABI was 8.4% and that of PAD among these patients 62.2%. PAD was significantly more prevalent among subjects with severe symptoms (rest pain, ulcers or gangrene) than in those with intermittent claudication (83.8% and 45.3%, respectively, p<0.001). The risk of PAD diagnosis was ten-fold (OR 10.31, 95% CI 2.07-51.30) among those with chronic renal failure, five-fold among patients with a history of smoking (OR 5.63, 95% CI 1.22-26.00) and over three-fold (OR 3.44, 95% CI 1.46-8.12) among those with coronary heart disease. The specificities of elevated ABI threshold levels (1.3, 1.4 and 1.5) in identifying PAD were 86%, 94% and 96%, respectively, the sensitivities being 44%, 38% and 36%, respectively.

CONCLUSIONS

The prevalence of elevated ABI in patients referred to vascular consultation is 8.4% and that of PAD among these 62.2%. PAD is significantly more probable among those with chronic renal failure, a history of smoking and coronary heart disease. Furthermore, the specificity of elevated ABI (>/=1.3) in recognizing PAD is good, whereas the sensitivity is only satisfactory.

Authors+Show Affiliations

Department of Surgery, Division of Vascular Surgery, Tampere University Hospital, Tampere, Finland. velipekka.suominen@pshp.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18313338

Citation

Suominen, V, et al. "Prevalence and Risk Factors of PAD Among Patients With Elevated ABI." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 35, no. 6, 2008, pp. 709-14.
Suominen V, Rantanen T, Venermo M, et al. Prevalence and risk factors of PAD among patients with elevated ABI. Eur J Vasc Endovasc Surg. 2008;35(6):709-14.
Suominen, V., Rantanen, T., Venermo, M., Saarinen, J., & Salenius, J. (2008). Prevalence and risk factors of PAD among patients with elevated ABI. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 35(6), 709-14. https://doi.org/10.1016/j.ejvs.2008.01.013
Suominen V, et al. Prevalence and Risk Factors of PAD Among Patients With Elevated ABI. Eur J Vasc Endovasc Surg. 2008;35(6):709-14. PubMed PMID: 18313338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors of PAD among patients with elevated ABI. AU - Suominen,V, AU - Rantanen,T, AU - Venermo,M, AU - Saarinen,J, AU - Salenius,J, Y1 - 2008/03/04/ PY - 2007/09/28/received PY - 2008/01/09/accepted PY - 2008/3/4/pubmed PY - 2008/6/13/medline PY - 2008/3/4/entrez SP - 709 EP - 14 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 35 IS - 6 N2 - OBJECTIVES: To assess the prevalence and clinical significance of elevated ankle-brachial index (ABI) in patients referred to vascular consultation. DESIGN: Retrospective clinical study. MATERIAL AND METHODS: In 1,762 patients referred with a suspicion of peripheral arterial disease (PAD), ABI and toe brachial index (TBI) were measured by photoplethysmography. ABI>/=1.3 was considered falsely elevated and TBI<0.60 was the diagnostic criterion for PAD. RESULTS: The prevalence of elevated ABI was 8.4% and that of PAD among these patients 62.2%. PAD was significantly more prevalent among subjects with severe symptoms (rest pain, ulcers or gangrene) than in those with intermittent claudication (83.8% and 45.3%, respectively, p<0.001). The risk of PAD diagnosis was ten-fold (OR 10.31, 95% CI 2.07-51.30) among those with chronic renal failure, five-fold among patients with a history of smoking (OR 5.63, 95% CI 1.22-26.00) and over three-fold (OR 3.44, 95% CI 1.46-8.12) among those with coronary heart disease. The specificities of elevated ABI threshold levels (1.3, 1.4 and 1.5) in identifying PAD were 86%, 94% and 96%, respectively, the sensitivities being 44%, 38% and 36%, respectively. CONCLUSIONS: The prevalence of elevated ABI in patients referred to vascular consultation is 8.4% and that of PAD among these 62.2%. PAD is significantly more probable among those with chronic renal failure, a history of smoking and coronary heart disease. Furthermore, the specificity of elevated ABI (>/=1.3) in recognizing PAD is good, whereas the sensitivity is only satisfactory. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/18313338/Prevalence_and_risk_factors_of_PAD_among_patients_with_elevated_ABI_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(08)00055-5 DB - PRIME DP - Unbound Medicine ER -