Tags

Type your tag names separated by a space and hit enter

Gingival primary extranodal non-Hodgkin's lymphoma as the first manifestation of acquired immunodeficiency syndrome.
J Periodontol. 2008 Mar; 79(3):562-6.JP

Abstract

BACKGROUND

Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative malignancies that may be associated with acquired immunodeficiency syndrome (AIDS). NHL can disseminate to extranodal sites; however, its dissemination to the jaws and mouth is not common. This report presents and discusses two unusual cases of gingival primary extranodal non-Hodgkin's lymphoma (PE-NHL) as the first manifestation of AIDS.

METHODS

Two males presented with asymptomatic gingival swelling. They were examined clinically. Biopsies of the gingival tissue were evaluated using routine histologic techniques and immunohistochemistry. The patients were tested for human immunodeficiency virus (HIV) infection.

RESULTS

The clinicopathological evaluation and the serological HIV examination of the patients led us to the final diagnosis of gingival PE-NHL as the first manifestation of AIDS. Both patients were referred to an oncologist and to an infectious disease specialist and were given antineoplastic chemotherapy and highly active antiretroviral therapy. Only one patient presented a favorable clinical evolution.

CONCLUSION

The present case reports have important clinical implications; the two unusual presentations of gingival PE-NHL contribute to information about the differential diagnosis of rapidly progressing gingival swelling.

Authors+Show Affiliations

Department of Oral Diagnosis and Surgery, Araraquara Dental School, São Paulo State University, Rua Humaitá 1680, Araraquara, SP, Brazil. cnavarro@foar.unesp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18315441

Citation

Navarro, Cláudia M., et al. "Gingival Primary Extranodal non-Hodgkin's Lymphoma as the First Manifestation of Acquired Immunodeficiency Syndrome." Journal of Periodontology, vol. 79, no. 3, 2008, pp. 562-6.
Navarro CM, Shibli JA, Ferrari RB, et al. Gingival primary extranodal non-Hodgkin's lymphoma as the first manifestation of acquired immunodeficiency syndrome. J Periodontol. 2008;79(3):562-6.
Navarro, C. M., Shibli, J. A., Ferrari, R. B., d'Avila, S., & Sposto, M. R. (2008). Gingival primary extranodal non-Hodgkin's lymphoma as the first manifestation of acquired immunodeficiency syndrome. Journal of Periodontology, 79(3), 562-6. https://doi.org/10.1902/jop.2008.070229
Navarro CM, et al. Gingival Primary Extranodal non-Hodgkin's Lymphoma as the First Manifestation of Acquired Immunodeficiency Syndrome. J Periodontol. 2008;79(3):562-6. PubMed PMID: 18315441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gingival primary extranodal non-Hodgkin's lymphoma as the first manifestation of acquired immunodeficiency syndrome. AU - Navarro,Cláudia M, AU - Shibli,Jamil A, AU - Ferrari,Roberto B, AU - d'Avila,Susana, AU - Sposto,Maria R, PY - 2008/3/5/pubmed PY - 2008/5/15/medline PY - 2008/3/5/entrez SP - 562 EP - 6 JF - Journal of periodontology JO - J Periodontol VL - 79 IS - 3 N2 - BACKGROUND: Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative malignancies that may be associated with acquired immunodeficiency syndrome (AIDS). NHL can disseminate to extranodal sites; however, its dissemination to the jaws and mouth is not common. This report presents and discusses two unusual cases of gingival primary extranodal non-Hodgkin's lymphoma (PE-NHL) as the first manifestation of AIDS. METHODS: Two males presented with asymptomatic gingival swelling. They were examined clinically. Biopsies of the gingival tissue were evaluated using routine histologic techniques and immunohistochemistry. The patients were tested for human immunodeficiency virus (HIV) infection. RESULTS: The clinicopathological evaluation and the serological HIV examination of the patients led us to the final diagnosis of gingival PE-NHL as the first manifestation of AIDS. Both patients were referred to an oncologist and to an infectious disease specialist and were given antineoplastic chemotherapy and highly active antiretroviral therapy. Only one patient presented a favorable clinical evolution. CONCLUSION: The present case reports have important clinical implications; the two unusual presentations of gingival PE-NHL contribute to information about the differential diagnosis of rapidly progressing gingival swelling. SN - 0022-3492 UR - https://www.unboundmedicine.com/medline/citation/18315441/Gingival_primary_extranodal_non_Hodgkin's_lymphoma_as_the_first_manifestation_of_acquired_immunodeficiency_syndrome_ L2 - https://doi.org/10.1902/jop.2008.070229 DB - PRIME DP - Unbound Medicine ER -