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Review article: nonalcoholic fatty liver disease and hepatitis C virus--partners in crime.
Aliment Pharmacol Ther. 2008 May; 27(10):855-65.AP

Abstract

BACKGROUND

Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) are frequent causes of chronic liver disease. In recent years, there have been significant revelations as regards the relationship between NAFLD and CHC.

AIM

To conduct a systematic, evidence-based review of the epidemiology, pathophysiology and potential treatments of coexistent NAFLD and CHC.

METHODS

The terms such as hepatitis C, fatty liver, NAFLD, nonalcoholic steatohepatitis and steatosis were searched on PubMed up to January 2008. References from selected articles and pertinent abstracts were also included.

RESULTS

Hepatic steatosis affects up to 80% of patients with CHC and is dependent on both viral and host factors. While insulin resistance (IR) is associated with hepatic steatosis and hepatitis C virus, genotype-specific pathogenic mechanisms have been identified and are currently the focus of intense investigation in the literature. Clinical implications of concurrent NAFLD, CHC and IR include increased disease progression, elevated risk of hepatocellular carcinoma, and decreased response to antiviral therapy.

CONCLUSIONS

NAFLD and IR are common in patients with CHC virus infection. IR is a driving force in the development of hepatic steatosis. Because of the clinical implications of hepatic steatosis and IR in the setting of CHC, further studies evaluating treatments, which may increase response to antiviral therapy, are needed.

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    Authors+Show Affiliations

    Blonsky JJ
    Division of Gastroenterology and Hepatology, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.
    Harrison SA
    No affiliation info available

    MeSH

    Antiviral AgentsCarcinoma, HepatocellularFatty LiverHepatitis CHumansLiver NeoplasmsObesityTreatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18315584

    Citation

    Blonsky, J J., and S A. Harrison. "Review Article: Nonalcoholic Fatty Liver Disease and Hepatitis C Virus--partners in Crime." Alimentary Pharmacology & Therapeutics, vol. 27, no. 10, 2008, pp. 855-65.
    Blonsky JJ, Harrison SA. Review article: nonalcoholic fatty liver disease and hepatitis C virus--partners in crime. Aliment Pharmacol Ther. 2008;27(10):855-65.
    Blonsky, J. J., & Harrison, S. A. (2008). Review article: nonalcoholic fatty liver disease and hepatitis C virus--partners in crime. Alimentary Pharmacology & Therapeutics, 27(10), 855-65. https://doi.org/10.1111/j.1365-2036.2008.03672.x
    Blonsky JJ, Harrison SA. Review Article: Nonalcoholic Fatty Liver Disease and Hepatitis C Virus--partners in Crime. Aliment Pharmacol Ther. 2008;27(10):855-65. PubMed PMID: 18315584.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Review article: nonalcoholic fatty liver disease and hepatitis C virus--partners in crime. AU - Blonsky,J J, AU - Harrison,S A, Y1 - 2008/02/29/ PY - 2008/3/5/pubmed PY - 2008/6/12/medline PY - 2008/3/5/entrez SP - 855 EP - 65 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 27 IS - 10 N2 - BACKGROUND: Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) are frequent causes of chronic liver disease. In recent years, there have been significant revelations as regards the relationship between NAFLD and CHC. AIM: To conduct a systematic, evidence-based review of the epidemiology, pathophysiology and potential treatments of coexistent NAFLD and CHC. METHODS: The terms such as hepatitis C, fatty liver, NAFLD, nonalcoholic steatohepatitis and steatosis were searched on PubMed up to January 2008. References from selected articles and pertinent abstracts were also included. RESULTS: Hepatic steatosis affects up to 80% of patients with CHC and is dependent on both viral and host factors. While insulin resistance (IR) is associated with hepatic steatosis and hepatitis C virus, genotype-specific pathogenic mechanisms have been identified and are currently the focus of intense investigation in the literature. Clinical implications of concurrent NAFLD, CHC and IR include increased disease progression, elevated risk of hepatocellular carcinoma, and decreased response to antiviral therapy. CONCLUSIONS: NAFLD and IR are common in patients with CHC virus infection. IR is a driving force in the development of hepatic steatosis. Because of the clinical implications of hepatic steatosis and IR in the setting of CHC, further studies evaluating treatments, which may increase response to antiviral therapy, are needed. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/18315584/Review_article:_nonalcoholic_fatty_liver_disease_and_hepatitis_C_virus__partners_in_crime_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03672.x DB - PRIME DP - Unbound Medicine ER -