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Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group.
J Clin Oncol. 2008 Apr 01; 26(10):1677-83.JC

Abstract

PURPOSE

Because they have large variations in consumption, Asian countries are suitable settings for studies of the effect of relatively high-dose isoflavone intake on breast cancer risk. Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake.

PATIENTS AND METHODS

A total of 24,226 women ages 40 to 69 years in the Japan Public Health Center-based prospective study who responded to the baseline questionnaire and provided blood in 1990 to 1995 were observed to December 2002. During a mean 10.6 years of follow-up, 144 patients newly diagnosed with breast cancer were identified. Two matched controls for each patient were selected from the cohort. Isoflavone levels were assessed by plasma level and food frequency questionnaire, and the odds ratio of breast cancer according to isoflavone level was estimated using a conditional logistic regression model.

RESULTS

We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups. Regarding dietary intake of isoflavones, nonsignificant inverse associations were observed for both genistein and daidzein.

CONCLUSION

This nested case-control study found an inverse association between plasma genistein and the risk of breast cancer in Japan.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. moiwasak@gan2.res.ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18316793

Citation

Iwasaki, Motoki, et al. "Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: a Nested Case-control Study From the Japan Public Health Center-based Prospective Study Group." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 26, no. 10, 2008, pp. 1677-83.
Iwasaki M, Inoue M, Otani T, et al. Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group. J Clin Oncol. 2008;26(10):1677-83.
Iwasaki, M., Inoue, M., Otani, T., Sasazuki, S., Kurahashi, N., Miura, T., Yamamoto, S., & Tsugane, S. (2008). Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 26(10), 1677-83. https://doi.org/10.1200/JCO.2007.13.9964
Iwasaki M, et al. Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: a Nested Case-control Study From the Japan Public Health Center-based Prospective Study Group. J Clin Oncol. 2008 Apr 1;26(10):1677-83. PubMed PMID: 18316793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group. AU - Iwasaki,Motoki, AU - Inoue,Manami, AU - Otani,Tetsuya, AU - Sasazuki,Shizuka, AU - Kurahashi,Norie, AU - Miura,Tsutomu, AU - Yamamoto,Seiichiro, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2008/03/03/ PY - 2008/3/5/pubmed PY - 2008/5/14/medline PY - 2008/3/5/entrez SP - 1677 EP - 83 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 26 IS - 10 N2 - PURPOSE: Because they have large variations in consumption, Asian countries are suitable settings for studies of the effect of relatively high-dose isoflavone intake on breast cancer risk. Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake. PATIENTS AND METHODS: A total of 24,226 women ages 40 to 69 years in the Japan Public Health Center-based prospective study who responded to the baseline questionnaire and provided blood in 1990 to 1995 were observed to December 2002. During a mean 10.6 years of follow-up, 144 patients newly diagnosed with breast cancer were identified. Two matched controls for each patient were selected from the cohort. Isoflavone levels were assessed by plasma level and food frequency questionnaire, and the odds ratio of breast cancer according to isoflavone level was estimated using a conditional logistic regression model. RESULTS: We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups. Regarding dietary intake of isoflavones, nonsignificant inverse associations were observed for both genistein and daidzein. CONCLUSION: This nested case-control study found an inverse association between plasma genistein and the risk of breast cancer in Japan. SN - 1527-7755 UR - https://www.unboundmedicine.com/medline/citation/18316793/Plasma_isoflavone_level_and_subsequent_risk_of_breast_cancer_among_Japanese_women:_a_nested_case_control_study_from_the_Japan_Public_Health_Center_based_prospective_study_group_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.2007.13.9964?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -