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Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age.
Pediatr Infect Dis J. 2008 Apr; 27(4):341-6.PI

Abstract

BACKGROUND

In the United States, diphtheria-tetanus-acellular pertussis (DTaP) and inactivated poliovirus (IPV) booster vaccinations are recommended for children 4-6 years of age. A combined DTaP-IPV vaccine is being developed, which would reduce by one the number of injections in this age group.

METHODS

Children 4-6 years of age were randomized (1:1:1:1) to receive booster vaccination with 1 of 3 combined DTaP-IPV lots plus the measles, mumps, and rubella vaccine (N = 3156 for pooled lots) or separate doses of DTaP + IPV + measles, mumps, and rubella vaccine (N = 1053). Immunogenicity was assessed in a subset of children (N = 1331). Safety (solicited and unsolicited symptoms) including detailed assessment of local swelling reactions, was assessed in all children.

RESULTS

Increases in antibody geometric mean concentrations/titers 1 month after vaccination were observed for the diphtheria, tetanus, acellular pertussis, and polio antigens. At least 92.2% of combined DTaP-IPV subjects and 92.6% of separate DTaP + IPV subjects had a postvaccination booster response for one or more DTaP antigens. Booster responses to one or more poliovirus antigens were observed in at least 96.6% of combined DTaP-IPV subjects and 92.8% of separate DTaP + IPV subjects. The combined DTaP-IPV vaccine was noninferior to separately administered DTaP and IPV vaccines with respect to DTaP antigen booster response rates and poliovirus antibody geometric mean titers ratios. Reporting of solicited local and systemic events was comparable between both groups.

CONCLUSIONS

The combination DTaP-IPV vaccine provided immunogenicity and reactogenicity that is comparable to separately administered DTaP and IPV vaccines, with the advantage of requiring one less injection.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Black S
Stanford University, Palo Alto, CA, USA.
Friedland LR
No affiliation info available
Ensor K
No affiliation info available
Weston WM
No affiliation info available
Howe B
No affiliation info available
Klein NP
No affiliation info available

MeSH

Antibodies, BacterialAntibodies, ViralChildChild, PreschoolDiphtheriaDiphtheria-Tetanus-acellular Pertussis VaccinesHumansImmunization, SecondaryMeasles VaccineMumps VaccinePoliomyelitisPoliovirus Vaccine, InactivatedRubella VaccineTetanusUnited StatesWhooping Cough

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18316985

Clinical Trial Links

Immune Response and Safety Comparison of 3 Lots of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP + IPV Vaccines

Citation

Black, Steven, et al. "Diphtheria-tetanus-acellular Pertussis and Inactivated Poliovirus Vaccines Given Separately or Combined for Booster Dosing at 4-6 Years of Age." The Pediatric Infectious Disease Journal, vol. 27, no. 4, 2008, pp. 341-6.
Black S, Friedland LR, Ensor K, et al. Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age. Pediatr Infect Dis J. 2008;27(4):341-6.
Black, S., Friedland, L. R., Ensor, K., Weston, W. M., Howe, B., & Klein, N. P. (2008). Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age. The Pediatric Infectious Disease Journal, 27(4), 341-6. https://doi.org/10.1097/INF.0b013e3181616180
Black S, et al. Diphtheria-tetanus-acellular Pertussis and Inactivated Poliovirus Vaccines Given Separately or Combined for Booster Dosing at 4-6 Years of Age. Pediatr Infect Dis J. 2008;27(4):341-6. PubMed PMID: 18316985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4-6 years of age. AU - Black,Steven, AU - Friedland,Leonard R, AU - Ensor,Kathleen, AU - Weston,Wayde M, AU - Howe,Barbara, AU - Klein,Nicola P, PY - 2008/3/5/pubmed PY - 2008/5/23/medline PY - 2008/3/5/entrez SP - 341 EP - 6 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 27 IS - 4 N2 - BACKGROUND: In the United States, diphtheria-tetanus-acellular pertussis (DTaP) and inactivated poliovirus (IPV) booster vaccinations are recommended for children 4-6 years of age. A combined DTaP-IPV vaccine is being developed, which would reduce by one the number of injections in this age group. METHODS: Children 4-6 years of age were randomized (1:1:1:1) to receive booster vaccination with 1 of 3 combined DTaP-IPV lots plus the measles, mumps, and rubella vaccine (N = 3156 for pooled lots) or separate doses of DTaP + IPV + measles, mumps, and rubella vaccine (N = 1053). Immunogenicity was assessed in a subset of children (N = 1331). Safety (solicited and unsolicited symptoms) including detailed assessment of local swelling reactions, was assessed in all children. RESULTS: Increases in antibody geometric mean concentrations/titers 1 month after vaccination were observed for the diphtheria, tetanus, acellular pertussis, and polio antigens. At least 92.2% of combined DTaP-IPV subjects and 92.6% of separate DTaP + IPV subjects had a postvaccination booster response for one or more DTaP antigens. Booster responses to one or more poliovirus antigens were observed in at least 96.6% of combined DTaP-IPV subjects and 92.8% of separate DTaP + IPV subjects. The combined DTaP-IPV vaccine was noninferior to separately administered DTaP and IPV vaccines with respect to DTaP antigen booster response rates and poliovirus antibody geometric mean titers ratios. Reporting of solicited local and systemic events was comparable between both groups. CONCLUSIONS: The combination DTaP-IPV vaccine provided immunogenicity and reactogenicity that is comparable to separately administered DTaP and IPV vaccines, with the advantage of requiring one less injection. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/18316985/Diphtheria_tetanus_acellular_pertussis_and_inactivated_poliovirus_vaccines_given_separately_or_combined_for_booster_dosing_at_4_6_years_of_age_ DB - PRIME DP - Unbound Medicine ER -