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Role of respiratory viral infections in the development of atopic conditions.
Curr Opin Allergy Clin Immunol. 2008 Apr; 8(2):150-3.CO

Abstract

PURPOSE OF REVIEW

Respiratory viral infections are implicated in both protection from, and inception of, allergic airway disease. Severe lower respiratory tract viral infections are associated with recurrent wheeze, asthma and atopy. It is unclear if this association is causal and the underlying mechanisms governing this are unknown. Whilst respiratory viral infections are the major precipitants of acute exacerbations of wheezing illness, early life infections are also clearly associated with protection from allergic diseases. This article aims to review the current understanding of the complex relationship between lower respiratory tract viral infections and their impact upon development of atopy in the airway.

RECENT FINDINGS

Clinical studies and animal models have further demonstrated that lower respiratory tract viral infections are strongly associated with development of recurrent wheeze and asthma with human rhinoviruses being shown to be the most prevalent cause of lower respiratory tract viral infections in infants, along with associated asthma development. A case-control study provided evidence of a contributory role for respiratory viral infections within this association, whilst recent experimental studies provide a possible mechanistic insight.

SUMMARY

Progress into understanding the relationship between respiratory viral infections and allergic airway disease is essential for development of treatments aimed at treating common risk factors mediating association but not cause. Recent findings may have begun to identify key pathways open to therapeutic intervention.

Authors+Show Affiliations

Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18317024

Citation

Walton, Ross P., and Sebastian L. Johnston. "Role of Respiratory Viral Infections in the Development of Atopic Conditions." Current Opinion in Allergy and Clinical Immunology, vol. 8, no. 2, 2008, pp. 150-3.
Walton RP, Johnston SL. Role of respiratory viral infections in the development of atopic conditions. Curr Opin Allergy Clin Immunol. 2008;8(2):150-3.
Walton, R. P., & Johnston, S. L. (2008). Role of respiratory viral infections in the development of atopic conditions. Current Opinion in Allergy and Clinical Immunology, 8(2), 150-3. https://doi.org/10.1097/ACI.0b013e3282f889df
Walton RP, Johnston SL. Role of Respiratory Viral Infections in the Development of Atopic Conditions. Curr Opin Allergy Clin Immunol. 2008;8(2):150-3. PubMed PMID: 18317024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of respiratory viral infections in the development of atopic conditions. AU - Walton,Ross P, AU - Johnston,Sebastian L, PY - 2008/3/5/pubmed PY - 2009/2/5/medline PY - 2008/3/5/entrez SP - 150 EP - 3 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 8 IS - 2 N2 - PURPOSE OF REVIEW: Respiratory viral infections are implicated in both protection from, and inception of, allergic airway disease. Severe lower respiratory tract viral infections are associated with recurrent wheeze, asthma and atopy. It is unclear if this association is causal and the underlying mechanisms governing this are unknown. Whilst respiratory viral infections are the major precipitants of acute exacerbations of wheezing illness, early life infections are also clearly associated with protection from allergic diseases. This article aims to review the current understanding of the complex relationship between lower respiratory tract viral infections and their impact upon development of atopy in the airway. RECENT FINDINGS: Clinical studies and animal models have further demonstrated that lower respiratory tract viral infections are strongly associated with development of recurrent wheeze and asthma with human rhinoviruses being shown to be the most prevalent cause of lower respiratory tract viral infections in infants, along with associated asthma development. A case-control study provided evidence of a contributory role for respiratory viral infections within this association, whilst recent experimental studies provide a possible mechanistic insight. SUMMARY: Progress into understanding the relationship between respiratory viral infections and allergic airway disease is essential for development of treatments aimed at treating common risk factors mediating association but not cause. Recent findings may have begun to identify key pathways open to therapeutic intervention. SN - 1528-4050 UR - https://www.unboundmedicine.com/medline/citation/18317024/Role_of_respiratory_viral_infections_in_the_development_of_atopic_conditions_ DB - PRIME DP - Unbound Medicine ER -