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Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease.
Alzheimer Dis Assoc Disord 2008 Jan-Mar; 22(1):61-5AD

Abstract

Alzheimer disease (AD) is the most frequent cause of dementia in Western countries. Putative genetic risk factors for AD are polymorphisms in the apolipoprotein E (APOE) gene and in the low-density lipoprotein receptor-related protein (LRP) gene. Our objective was to investigate the role of the APOE coding region polymorphisms epsilon 2, epsilon 3, and epsilon 4 and APOE promoter variants A/T at position -491 and G/T at -219, as well as LRP polymorphism C/T, as risk factors for AD in Brazilian individuals. One hundred and twenty patients with probable AD, along with 120 controls were analyzed. A significant difference between patients and controls for epsilon 4 alleles was observed: frequency of this allele in AD was 0.31, and 0.10 in controls. Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele; presence of 1 epsilon 2 allele proved protective. The presence of the T allele of the -219 polymorphism was also associated with an increased risk of AD, but this polymorphism is in linkage disequilibrium with APOE epsilon polymorphisms. No significant differences between patients and controls were observed for -491 APOE or LRP polymorphisms. In this Brazilian population, both the epsilon 4 allele and T -219 polymorphism were associated with an increased risk for AD.

Authors+Show Affiliations

Behavioral and Cognitive Neurology Unit, Department of Neurology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil. vs.bahia@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18317248

Citation

Bahia, Valéria Santoro, et al. "Polymorphisms of APOE and LRP Genes in Brazilian Individuals With Alzheimer Disease." Alzheimer Disease and Associated Disorders, vol. 22, no. 1, 2008, pp. 61-5.
Bahia VS, Kok F, Marie SN, et al. Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. Alzheimer Dis Assoc Disord. 2008;22(1):61-5.
Bahia, V. S., Kok, F., Marie, S. N., Shinjo, S. O., Caramelli, P., & Nitrini, R. (2008). Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. Alzheimer Disease and Associated Disorders, 22(1), pp. 61-5. doi:10.1097/WAD.0b013e31815a9da7.
Bahia VS, et al. Polymorphisms of APOE and LRP Genes in Brazilian Individuals With Alzheimer Disease. Alzheimer Dis Assoc Disord. 2008;22(1):61-5. PubMed PMID: 18317248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. AU - Bahia,Valéria Santoro, AU - Kok,Fernando, AU - Marie,Suely Nagahashi, AU - Shinjo,Sueli Oba, AU - Caramelli,Paulo, AU - Nitrini,Ricardo, PY - 2008/3/5/pubmed PY - 2008/5/21/medline PY - 2008/3/5/entrez SP - 61 EP - 5 JF - Alzheimer disease and associated disorders JO - Alzheimer Dis Assoc Disord VL - 22 IS - 1 N2 - Alzheimer disease (AD) is the most frequent cause of dementia in Western countries. Putative genetic risk factors for AD are polymorphisms in the apolipoprotein E (APOE) gene and in the low-density lipoprotein receptor-related protein (LRP) gene. Our objective was to investigate the role of the APOE coding region polymorphisms epsilon 2, epsilon 3, and epsilon 4 and APOE promoter variants A/T at position -491 and G/T at -219, as well as LRP polymorphism C/T, as risk factors for AD in Brazilian individuals. One hundred and twenty patients with probable AD, along with 120 controls were analyzed. A significant difference between patients and controls for epsilon 4 alleles was observed: frequency of this allele in AD was 0.31, and 0.10 in controls. Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele; presence of 1 epsilon 2 allele proved protective. The presence of the T allele of the -219 polymorphism was also associated with an increased risk of AD, but this polymorphism is in linkage disequilibrium with APOE epsilon polymorphisms. No significant differences between patients and controls were observed for -491 APOE or LRP polymorphisms. In this Brazilian population, both the epsilon 4 allele and T -219 polymorphism were associated with an increased risk for AD. SN - 0893-0341 UR - https://www.unboundmedicine.com/medline/citation/18317248/Polymorphisms_of_APOE_and_LRP_genes_in_Brazilian_individuals_with_Alzheimer_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=18317248 DB - PRIME DP - Unbound Medicine ER -