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Influence of fish oil on blood lipids in coronary artery disease.
Eur J Clin Nutr. 1991 Apr; 45(4):209-13.EJ

Abstract

The low incidence of coronary artery disease in Greenland Eskimos may be due to their intake of seafood with a high content of n-3 polyunsaturated fatty acids which may have a hypolipidaemic effect. Results of previous studies have been controversial, depending on the dosage of fish oil and the phenotypic cause of the hyperlipoproteinaemia. In this placebo-controlled, double-blind, cross-over study, patients (n = 32) with coronary artery disease and dyslipidaemia received firstly 2.4 g eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Thereafter in the open study the same study group received 3.6 g EPA/DHA. Fish oil had no significant effect on serum cholesterol or high density lipoprotein (HDL) cholesterol. Low doses of fish oil (2.4 g EPA/DHA) reduced serum triglyceride level significantly (P less than 0.05) and more significantly (P less than 0.01) with 3.6 g EPA/DHA. The results indicated that the therapeutic effect of n-3 fatty acids as hypolipidaemic agents is greatest in patients with severe hypertriglyceridaemia (greater than 3.00 mmol/l).

Authors+Show Affiliations

Department of Clinical Sciences, University of Tampere, Finland.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1831755

Citation

Nikkilä, M. "Influence of Fish Oil On Blood Lipids in Coronary Artery Disease." European Journal of Clinical Nutrition, vol. 45, no. 4, 1991, pp. 209-13.
Nikkilä M. Influence of fish oil on blood lipids in coronary artery disease. Eur J Clin Nutr. 1991;45(4):209-13.
Nikkilä, M. (1991). Influence of fish oil on blood lipids in coronary artery disease. European Journal of Clinical Nutrition, 45(4), 209-13.
Nikkilä M. Influence of Fish Oil On Blood Lipids in Coronary Artery Disease. Eur J Clin Nutr. 1991;45(4):209-13. PubMed PMID: 1831755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of fish oil on blood lipids in coronary artery disease. A1 - Nikkilä,M, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 209 EP - 13 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 45 IS - 4 N2 - The low incidence of coronary artery disease in Greenland Eskimos may be due to their intake of seafood with a high content of n-3 polyunsaturated fatty acids which may have a hypolipidaemic effect. Results of previous studies have been controversial, depending on the dosage of fish oil and the phenotypic cause of the hyperlipoproteinaemia. In this placebo-controlled, double-blind, cross-over study, patients (n = 32) with coronary artery disease and dyslipidaemia received firstly 2.4 g eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Thereafter in the open study the same study group received 3.6 g EPA/DHA. Fish oil had no significant effect on serum cholesterol or high density lipoprotein (HDL) cholesterol. Low doses of fish oil (2.4 g EPA/DHA) reduced serum triglyceride level significantly (P less than 0.05) and more significantly (P less than 0.01) with 3.6 g EPA/DHA. The results indicated that the therapeutic effect of n-3 fatty acids as hypolipidaemic agents is greatest in patients with severe hypertriglyceridaemia (greater than 3.00 mmol/l). SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/1831755/Influence_of_fish_oil_on_blood_lipids_in_coronary_artery_disease_ L2 - https://www.lens.org/lens/search?q=citation_id:1831755 DB - PRIME DP - Unbound Medicine ER -