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Multimodal virtual bronchoscopy using PET/CT images.
Comput Aided Surg. 2008 Mar; 13(2):106-13.CA

Abstract

OBJECTIVE

To demonstrate the possibilities, advantages and limitations of virtual bronchoscopy using data sets from positron emission tomography (PET) and computed tomography (CT).

MATERIALS AND METHODS

Eight consecutive patients with non-small cell lung cancer (NSCLC) underwent PET/CT. PET was performed with a glucose analog, 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG), using a state-of-the-art full-ring Pico-3D PET scanner. CT was performed with a venous-dominant contrast-enhanced phase using a 16-slice CT scanner. The tracheobronchial system was segmented using the CT data set with an interactive threshold interval volume-growing segmentation algorithm. The primary tumors and lymph node metastases were segmented for virtual CT-bronchoscopy using the CT data set and for virtual hybrid bronchoscopy using the PET/CT data set. The structures of interest were visualized with a color-coded shaded-surface rendering method.

RESULTS

The use of CT and virtual CT-bronchoscopy primarily facilitates visualization of the anatomical details of the tracheobronchial system and detection of anatomical/morphologic structural changes caused by disease. PET/CT and virtual hybrid bronchoscopy, or virtual PET/CT-bronchoscopy, give superior results to virtual CT-bronchoscopy because the hybrid bronchoscopy uses both the CT information and the molecular/metabolic information about the disease obtained from PET.

CONCLUSIONS

PET/CT imaging has proven to be a highly valuable oncological diagnostic modality. Virtual hybrid bronchoscopy can be performed using a low-dose CT scan or diagnostic CT. However, it is expected to improve diagnostic accuracy in identification and characterization of malignancies, verification of infections, and differentiation of viable tumor tissue from atelectases and scar tissue, as well as assessment of tumor staging and therapeutic response, and detection of early stage recurrences that are not detectable or are liable to be misjudged using virtual CT-bronchoscopy. It could also be useful as a screening examination method for patients with suspected endobronchial malignancy. Virtual hybrid bronchoscopy with a transparent color-coded shaded-surface rendering model offers a useful alternative to fiberoptic bronchoscopy, and is particularly promising for patients for whom fiberoptic bronchoscopy is not feasible, contraindicated or refused.

Authors+Show Affiliations

Institute for Biomedical and Medical Imaging, Helholz Center Munich, Munich, Germany. englmeier@gsf.deNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18317959

Citation

Englmeier, Karl-Hans, and Marcus D. Seemann. "Multimodal Virtual Bronchoscopy Using PET/CT Images." Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery, vol. 13, no. 2, 2008, pp. 106-13.
Englmeier KH, Seemann MD. Multimodal virtual bronchoscopy using PET/CT images. Comput Aided Surg. 2008;13(2):106-13.
Englmeier, K. H., & Seemann, M. D. (2008). Multimodal virtual bronchoscopy using PET/CT images. Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery, 13(2), 106-13. https://doi.org/10.3109/10929080801954164
Englmeier KH, Seemann MD. Multimodal Virtual Bronchoscopy Using PET/CT Images. Comput Aided Surg. 2008;13(2):106-13. PubMed PMID: 18317959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multimodal virtual bronchoscopy using PET/CT images. AU - Englmeier,Karl-Hans, AU - Seemann,Marcus D, PY - 2008/3/5/pubmed PY - 2008/7/18/medline PY - 2008/3/5/entrez SP - 106 EP - 13 JF - Computer aided surgery : official journal of the International Society for Computer Aided Surgery JO - Comput. Aided Surg. VL - 13 IS - 2 N2 - OBJECTIVE: To demonstrate the possibilities, advantages and limitations of virtual bronchoscopy using data sets from positron emission tomography (PET) and computed tomography (CT). MATERIALS AND METHODS: Eight consecutive patients with non-small cell lung cancer (NSCLC) underwent PET/CT. PET was performed with a glucose analog, 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG), using a state-of-the-art full-ring Pico-3D PET scanner. CT was performed with a venous-dominant contrast-enhanced phase using a 16-slice CT scanner. The tracheobronchial system was segmented using the CT data set with an interactive threshold interval volume-growing segmentation algorithm. The primary tumors and lymph node metastases were segmented for virtual CT-bronchoscopy using the CT data set and for virtual hybrid bronchoscopy using the PET/CT data set. The structures of interest were visualized with a color-coded shaded-surface rendering method. RESULTS: The use of CT and virtual CT-bronchoscopy primarily facilitates visualization of the anatomical details of the tracheobronchial system and detection of anatomical/morphologic structural changes caused by disease. PET/CT and virtual hybrid bronchoscopy, or virtual PET/CT-bronchoscopy, give superior results to virtual CT-bronchoscopy because the hybrid bronchoscopy uses both the CT information and the molecular/metabolic information about the disease obtained from PET. CONCLUSIONS: PET/CT imaging has proven to be a highly valuable oncological diagnostic modality. Virtual hybrid bronchoscopy can be performed using a low-dose CT scan or diagnostic CT. However, it is expected to improve diagnostic accuracy in identification and characterization of malignancies, verification of infections, and differentiation of viable tumor tissue from atelectases and scar tissue, as well as assessment of tumor staging and therapeutic response, and detection of early stage recurrences that are not detectable or are liable to be misjudged using virtual CT-bronchoscopy. It could also be useful as a screening examination method for patients with suspected endobronchial malignancy. Virtual hybrid bronchoscopy with a transparent color-coded shaded-surface rendering model offers a useful alternative to fiberoptic bronchoscopy, and is particularly promising for patients for whom fiberoptic bronchoscopy is not feasible, contraindicated or refused. SN - 1092-9088 UR - https://www.unboundmedicine.com/medline/citation/18317959/Multimodal_virtual_bronchoscopy_using_PET/CT_images_ L2 - http://www.tandfonline.com/doi/full/10.3109/10929080801954164 DB - PRIME DP - Unbound Medicine ER -