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Development of vaccine strains of H5 and H7 influenza viruses.
Jpn J Vet Res 2008; 55(2-3):93-8JJ

Abstract

To establish vaccine strains of H5 and H7 influenza viruses, A/duck/Hokkaido/Vac-1/04 (H5N1) [Vac-1/04 (H5N1)], A/duck/Hokkaido/Vac-3/07 (H5N1) [Vac-3/07 (H5N1)], and A/duck/Hokkaido/ Vac-2/04 (H7N7) [Vac-2/04 (H7N7)] were generated from non-pathogenic avian influenza viruses isolated from migratory ducks. Vac-1/04 (H5N1) and Vac-3/07 (H5N1) were generated by genetic reassortment between H5N2 or H5N3 virus as an HA gene provider and H7N1 or H6N1 viruses as an NA gene provider. Vac-2/04 (H7N7) was a genetic reassortant obtained using H7N7 and H9 N2 viruses to give high growth character of the H9N2 virus in chicken embryonated eggs. The results of sequence analyses and experimental infections revealed that these H5N1 and H7N7 reassortant viruses were non-pathogenic in chickens and embryos, and had good growth potential in embryonated eggs. These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses.

Authors+Show Affiliations

Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18318111

Citation

Soda, Kosuke, et al. "Development of Vaccine Strains of H5 and H7 Influenza Viruses." The Japanese Journal of Veterinary Research, vol. 55, no. 2-3, 2008, pp. 93-8.
Soda K, Sakoda Y, Isoda N, et al. Development of vaccine strains of H5 and H7 influenza viruses. Jpn J Vet Res. 2008;55(2-3):93-8.
Soda, K., Sakoda, Y., Isoda, N., Kajihara, M., Haraguchi, Y., Shibuya, H., ... Kida, H. (2008). Development of vaccine strains of H5 and H7 influenza viruses. The Japanese Journal of Veterinary Research, 55(2-3), pp. 93-8.
Soda K, et al. Development of Vaccine Strains of H5 and H7 Influenza Viruses. Jpn J Vet Res. 2008;55(2-3):93-8. PubMed PMID: 18318111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of vaccine strains of H5 and H7 influenza viruses. AU - Soda,Kosuke, AU - Sakoda,Yoshihiro, AU - Isoda,Norikazu, AU - Kajihara,Masahiro, AU - Haraguchi,Yoshinari, AU - Shibuya,Hitomi, AU - Yoshida,Hiromi, AU - Sasaki,Takashi, AU - Sakamoto,Ryuichi, AU - Saijo,Kazue, AU - Hagiwara,Junko, AU - Kida,Hiroshi, PY - 2008/3/6/pubmed PY - 2008/3/25/medline PY - 2008/3/6/entrez SP - 93 EP - 8 JF - The Japanese journal of veterinary research JO - Jpn. J. Vet. Res. VL - 55 IS - 2-3 N2 - To establish vaccine strains of H5 and H7 influenza viruses, A/duck/Hokkaido/Vac-1/04 (H5N1) [Vac-1/04 (H5N1)], A/duck/Hokkaido/Vac-3/07 (H5N1) [Vac-3/07 (H5N1)], and A/duck/Hokkaido/ Vac-2/04 (H7N7) [Vac-2/04 (H7N7)] were generated from non-pathogenic avian influenza viruses isolated from migratory ducks. Vac-1/04 (H5N1) and Vac-3/07 (H5N1) were generated by genetic reassortment between H5N2 or H5N3 virus as an HA gene provider and H7N1 or H6N1 viruses as an NA gene provider. Vac-2/04 (H7N7) was a genetic reassortant obtained using H7N7 and H9 N2 viruses to give high growth character of the H9N2 virus in chicken embryonated eggs. The results of sequence analyses and experimental infections revealed that these H5N1 and H7N7 reassortant viruses were non-pathogenic in chickens and embryos, and had good growth potential in embryonated eggs. These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses. SN - 0047-1917 UR - https://www.unboundmedicine.com/medline/citation/18318111/Development_of_vaccine_strains_of_H5_and_H7_influenza_viruses_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0047-1917&volume=55&issue=2-3&spage=93 DB - PRIME DP - Unbound Medicine ER -