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Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.
J Cell Mol Med. 2008 Dec; 12(6B):2762-71.JC

Abstract

The risk of dementia and Alzheimer's disease (AD) probably results from an interaction between genetic and environmental factors. The aim of this study was to investigate the effects and putative interactions between the apoE epsilon4 allele and lifestyle related risk factors for dementia and AD. Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982 or 1987. After an average follow-up of 21 years, 1449 individuals (72.5%) aged 65-79 years were re-examined in 1998. The apoE epsilon4 allele was an independent risk factor for dementia/AD even after adjustments for sociodemographic, lifestyle and vascular factors (odds ratio [OR]=2.83, 95% confidence interval [CI]=1.61-4.97). Physical inactivity, alcohol drinking and smoking increased the risk of dementia/AD particularly among the apoE epsilon4 carriers. Furthermore, low-moderate intake of polyunsaturated, and moderate-high intake of saturated fats were associated with an increased risk of dementia/AD more pronouncedly among apoE epsilon4 carriers. Composite effect of the lifestyle factors was particularly seen among the epsilon4 carriers (OR=11.42, 95% CI=1.94-67.07 in the 4th quartile). Physical inactivity, dietary fat intake, alcohol drinking and smoking at midlife are associated with the risk of dementia and AD, especially among the apoE epsilon4 carriers. The apoE epsilon4 carriers may be more vulnerable to environmental factors, and thus, lifestyle interventions may greatly modify dementia risk particularly among the genetically susceptible individuals.

Authors+Show Affiliations

Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden. Miia.Kivipelto@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18318693

Citation

Kivipelto, Miia, et al. "Apolipoprotein E Epsilon4 Magnifies Lifestyle Risks for Dementia: a Population-based Study." Journal of Cellular and Molecular Medicine, vol. 12, no. 6B, 2008, pp. 2762-71.
Kivipelto M, Rovio S, Ngandu T, et al. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. J Cell Mol Med. 2008;12(6B):2762-71.
Kivipelto, M., Rovio, S., Ngandu, T., Kåreholt, I., Eskelinen, M., Winblad, B., Hachinski, V., Cedazo-Minguez, A., Soininen, H., Tuomilehto, J., & Nissinen, A. (2008). Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. Journal of Cellular and Molecular Medicine, 12(6B), 2762-71. https://doi.org/10.1111/j.1582-4934.2008.00296.x
Kivipelto M, et al. Apolipoprotein E Epsilon4 Magnifies Lifestyle Risks for Dementia: a Population-based Study. J Cell Mol Med. 2008;12(6B):2762-71. PubMed PMID: 18318693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. AU - Kivipelto,Miia, AU - Rovio,Suvi, AU - Ngandu,Tiia, AU - Kåreholt,Ingemar, AU - Eskelinen,Marjo, AU - Winblad,Bengt, AU - Hachinski,Vladimir, AU - Cedazo-Minguez,Angel, AU - Soininen,Hilkka, AU - Tuomilehto,Jaakko, AU - Nissinen,Aulikki, Y1 - 2008/02/08/ PY - 2008/3/6/pubmed PY - 2009/3/26/medline PY - 2008/3/6/entrez SP - 2762 EP - 71 JF - Journal of cellular and molecular medicine JO - J. Cell. Mol. Med. VL - 12 IS - 6B N2 - The risk of dementia and Alzheimer's disease (AD) probably results from an interaction between genetic and environmental factors. The aim of this study was to investigate the effects and putative interactions between the apoE epsilon4 allele and lifestyle related risk factors for dementia and AD. Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982 or 1987. After an average follow-up of 21 years, 1449 individuals (72.5%) aged 65-79 years were re-examined in 1998. The apoE epsilon4 allele was an independent risk factor for dementia/AD even after adjustments for sociodemographic, lifestyle and vascular factors (odds ratio [OR]=2.83, 95% confidence interval [CI]=1.61-4.97). Physical inactivity, alcohol drinking and smoking increased the risk of dementia/AD particularly among the apoE epsilon4 carriers. Furthermore, low-moderate intake of polyunsaturated, and moderate-high intake of saturated fats were associated with an increased risk of dementia/AD more pronouncedly among apoE epsilon4 carriers. Composite effect of the lifestyle factors was particularly seen among the epsilon4 carriers (OR=11.42, 95% CI=1.94-67.07 in the 4th quartile). Physical inactivity, dietary fat intake, alcohol drinking and smoking at midlife are associated with the risk of dementia and AD, especially among the apoE epsilon4 carriers. The apoE epsilon4 carriers may be more vulnerable to environmental factors, and thus, lifestyle interventions may greatly modify dementia risk particularly among the genetically susceptible individuals. SN - 1582-1838 UR - https://www.unboundmedicine.com/medline/citation/18318693/Apolipoprotein_E_epsilon4_magnifies_lifestyle_risks_for_dementia:_a_population_based_study_ L2 - https://doi.org/10.1111/j.1582-4934.2008.00296.x DB - PRIME DP - Unbound Medicine ER -