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The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study.
Pediatr Allergy Immunol. 2008 Dec; 19(8):737-45.PA

Abstract

This study determines the prevalence of atopic dermatitis, asthma, rhinoconjunctivitis, food hypersensitivity and urticaria and the frequency of sensitization in children with and without clinical allergic disease. In an ongoing prospective non-interventional birth cohort study of 562 unselected children, 404 children were subjected to interview, clinical examination, lung function measurements and allergy testing at 6 yr of age. Sensitization measured by skin prick test (SPT) and specific immunoglobulin E (S-IgE) was determined for 24 different allergens. The 1-yr period prevalence of atopic dermatitis, asthma and rhinoconjunctivitis was 14.4%, 6.2% and 13.6%. 25.7% of the children suffered from at least one of the three diseases. The frequency of sensitization in children with no disease (controls), any allergic disease, atopic dermatitis, asthma and rhinoconjunctivitis was 17%, 45%, 47%, 56% and 55% (defined as SPT >or=3 mm and/or S-IgE >or=0.35 kU/l for at least one allergen). Symptoms were linked to sensitization for 44% in the asthma group and 42% in the rhinoconjunctivitis group, whereas sensitization could not be linked to worsening of the eczema in any cases of atopic dermatitis. Overlap between the three diseases was significantly more frequent in sensitized children than in non-sensitized (19/46 = 41% vs. 9/58 = 16%, p = 0.004). The prevalence of food hypersensitivity and urticaria was 1.2% and 5.4% respectively. In unselected 6 yr old children, approximately half of the children with atopic dermatitis, asthma or rhinoconjunctivitis are IgE-sensitized. Sensitization tends to link these diseases to each other.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kjaer HF
Department of Dermatology, Odense University Hospital, University of Southern Denmark, Odense, Denmark. henrik.fomsgaard.kjaer@ouh.regionsyddanmark.dk
Eller E
No affiliation info available
Høst A
No affiliation info available
Andersen KE
No affiliation info available
Bindslev-Jensen C
No affiliation info available

MeSH

AllergensAsthmaChildChild, PreschoolCohort StudiesConjunctivitis, AllergicDenmarkDermatitis, AtopicFemaleFollow-Up StudiesFood HypersensitivityHumansHypersensitivity, ImmediateImmunoglobulin EInfantInfant, NewbornMalePrevalenceProspective StudiesSkin TestsUrticaria

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18318699

Citation

Kjaer, Henrik Fomsgaard, et al. "The Prevalence of Allergic Diseases in an Unselected Group of 6-year-old Children. the DARC Birth Cohort Study." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 19, no. 8, 2008, pp. 737-45.
Kjaer HF, Eller E, Høst A, et al. The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatr Allergy Immunol. 2008;19(8):737-45.
Kjaer, H. F., Eller, E., Høst, A., Andersen, K. E., & Bindslev-Jensen, C. (2008). The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 19(8), 737-45. https://doi.org/10.1111/j.1399-3038.2008.00733.x
Kjaer HF, et al. The Prevalence of Allergic Diseases in an Unselected Group of 6-year-old Children. the DARC Birth Cohort Study. Pediatr Allergy Immunol. 2008;19(8):737-45. PubMed PMID: 18318699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. AU - Kjaer,Henrik Fomsgaard, AU - Eller,Esben, AU - Høst,Arne, AU - Andersen,Klaus Ejner, AU - Bindslev-Jensen,Carsten, Y1 - 2008/03/03/ PY - 2008/3/6/entrez PY - 2008/3/6/pubmed PY - 2009/5/16/medline SP - 737 EP - 45 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 19 IS - 8 N2 - This study determines the prevalence of atopic dermatitis, asthma, rhinoconjunctivitis, food hypersensitivity and urticaria and the frequency of sensitization in children with and without clinical allergic disease. In an ongoing prospective non-interventional birth cohort study of 562 unselected children, 404 children were subjected to interview, clinical examination, lung function measurements and allergy testing at 6 yr of age. Sensitization measured by skin prick test (SPT) and specific immunoglobulin E (S-IgE) was determined for 24 different allergens. The 1-yr period prevalence of atopic dermatitis, asthma and rhinoconjunctivitis was 14.4%, 6.2% and 13.6%. 25.7% of the children suffered from at least one of the three diseases. The frequency of sensitization in children with no disease (controls), any allergic disease, atopic dermatitis, asthma and rhinoconjunctivitis was 17%, 45%, 47%, 56% and 55% (defined as SPT >or=3 mm and/or S-IgE >or=0.35 kU/l for at least one allergen). Symptoms were linked to sensitization for 44% in the asthma group and 42% in the rhinoconjunctivitis group, whereas sensitization could not be linked to worsening of the eczema in any cases of atopic dermatitis. Overlap between the three diseases was significantly more frequent in sensitized children than in non-sensitized (19/46 = 41% vs. 9/58 = 16%, p = 0.004). The prevalence of food hypersensitivity and urticaria was 1.2% and 5.4% respectively. In unselected 6 yr old children, approximately half of the children with atopic dermatitis, asthma or rhinoconjunctivitis are IgE-sensitized. Sensitization tends to link these diseases to each other. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/18318699/The_prevalence_of_allergic_diseases_in_an_unselected_group_of_6_year_old_children__The_DARC_birth_cohort_study_ DB - PRIME DP - Unbound Medicine ER -