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Validation of the HCC-MELD for dropout probability in patients with small hepatocellular carcinoma undergoing locoregional therapy.
Clin Transplant. 2008 Jul-Aug; 22(4):469-75.CT

Abstract

BACKGROUND

The model for end-stage liver disease (MELD) is used in prioritizing cirrhotic patients awaiting liver transplantation. Patients with small hepatocellular carcinoma (HCC) are eligible candidates. An HCC-MELD equation was recently proposed to predict the dropout rate of HCC patients on the waiting list. This study aimed to validate the accuracy of this equation.

METHODS

We investigated 390 patients with small HCC who were candidates for liver transplantation and underwent locoregional therapy.

RESULTS

The estimated probability of dropout according to the equation was 8.2% for T1 stage and 13.5% for T2 stage HCC (p < 0.0001). The actual disease progression rate at three months was 2.1% for T1 and 3.0% for T2 stage HCC. At six months, the progression rate was 5.3% for T1 stage and 6.8% for T2 stage. The area under receiver operating characteristic curve of the HCC-MELD equation was 0.81 at three months and 0.80 at six months. Patients undergoing radiofrequency ablation (RFA) had significantly lower dropout rates compared with other treatment groups according to the equation (p = 0.0007). The actual tumor progression rate was also the lowest for the RFA group at both three and six months.

CONCLUSION

The HCC-MELD equation is a feasible predictive model for patients with small HCC undergoing locoregional therapy.

Authors+Show Affiliations

Department of Medicine, Taipet Veterans General Hospital, Taipei, Taiwan. tihuo@vghtpe.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

18318736

Citation

Huo, Teh-Ia, et al. "Validation of the HCC-MELD for Dropout Probability in Patients With Small Hepatocellular Carcinoma Undergoing Locoregional Therapy." Clinical Transplantation, vol. 22, no. 4, 2008, pp. 469-75.
Huo TI, Huang YH, Su CW, et al. Validation of the HCC-MELD for dropout probability in patients with small hepatocellular carcinoma undergoing locoregional therapy. Clin Transplant. 2008;22(4):469-75.
Huo, T. I., Huang, Y. H., Su, C. W., Lin, H. C., Chiang, J. H., Chiou, Y. Y., Huo, S. C., Lee, P. C., & Lee, S. D. (2008). Validation of the HCC-MELD for dropout probability in patients with small hepatocellular carcinoma undergoing locoregional therapy. Clinical Transplantation, 22(4), 469-75. https://doi.org/10.1111/j.1399-0012.2008.00811.x
Huo TI, et al. Validation of the HCC-MELD for Dropout Probability in Patients With Small Hepatocellular Carcinoma Undergoing Locoregional Therapy. Clin Transplant. 2008 Jul-Aug;22(4):469-75. PubMed PMID: 18318736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the HCC-MELD for dropout probability in patients with small hepatocellular carcinoma undergoing locoregional therapy. AU - Huo,Teh-Ia, AU - Huang,Yi-Hsiang, AU - Su,Chien-Wei, AU - Lin,Han-Chieh, AU - Chiang,Jen-Huei, AU - Chiou,Yi-You, AU - Huo,Samantha C, AU - Lee,Pui-Ching, AU - Lee,Shou-Dong, Y1 - 2008/03/03/ PY - 2008/3/6/pubmed PY - 2008/12/19/medline PY - 2008/3/6/entrez SP - 469 EP - 75 JF - Clinical transplantation JO - Clin Transplant VL - 22 IS - 4 N2 - BACKGROUND: The model for end-stage liver disease (MELD) is used in prioritizing cirrhotic patients awaiting liver transplantation. Patients with small hepatocellular carcinoma (HCC) are eligible candidates. An HCC-MELD equation was recently proposed to predict the dropout rate of HCC patients on the waiting list. This study aimed to validate the accuracy of this equation. METHODS: We investigated 390 patients with small HCC who were candidates for liver transplantation and underwent locoregional therapy. RESULTS: The estimated probability of dropout according to the equation was 8.2% for T1 stage and 13.5% for T2 stage HCC (p < 0.0001). The actual disease progression rate at three months was 2.1% for T1 and 3.0% for T2 stage HCC. At six months, the progression rate was 5.3% for T1 stage and 6.8% for T2 stage. The area under receiver operating characteristic curve of the HCC-MELD equation was 0.81 at three months and 0.80 at six months. Patients undergoing radiofrequency ablation (RFA) had significantly lower dropout rates compared with other treatment groups according to the equation (p = 0.0007). The actual tumor progression rate was also the lowest for the RFA group at both three and six months. CONCLUSION: The HCC-MELD equation is a feasible predictive model for patients with small HCC undergoing locoregional therapy. SN - 1399-0012 UR - https://www.unboundmedicine.com/medline/citation/18318736/Validation_of_the_HCC_MELD_for_dropout_probability_in_patients_with_small_hepatocellular_carcinoma_undergoing_locoregional_therapy_ L2 - https://doi.org/10.1111/j.1399-0012.2008.00811.x DB - PRIME DP - Unbound Medicine ER -