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[Genetic polymorphism of the E apolipoprotein in school age children: comparison with levels of plasma lipids and apolipoproteins].
Biomedica. 2007 Dec; 27(4):526-36.B

Abstract

INTRODUCTION

Research in laboratories around the world has documented the contribution of the E apolipoprotein alleles to structural variations of lipids and apolipoproteins.

OBJECTIVE

The gene frequencies of the E apolipoprotein alleles were compared with the lipid and apolipoprotein levels in school age children.

MATERIALS AND METHODS

Six hundred and ninety one 5 to 15 years old school age children from the Colombian departments of Cundinamarca, Boyacá, Meta, Santander and Norte de Santander, were evaluated. The genotypes of the E apolipoprotein were identified by polymerase chain reaction-restriction fragment length polymorphism. Plasma levels for the following 5 lipids and lipoproteins were assayed: total cholesterol, HDL (high density lipoprotein) cholesterol, LDL (low density lipoprotein) cholesterol, triglycerides, VLDL (very low density lipoprotein) cholesterol, A-I apolipoprotein and B-100 apolipoprotein.

RESULTS

Alleles e2, e3 and e4 were found in frequencies of 0.04, 0.86 and 0.08, respectively. The E4 group (E4/3-E4/4), in contrast with the E2 group (E3/2-E2/2), presented highest plasma concentrations of total cholesterol, LDL cholesterol and B-100 apolipoprotein (p=0.014, 0.001 and 0.000, respectively). When the E3/3 group was compared with E2, the same result was obtained (p=0.015, 0.002 and 0.002, respectively). The influence of the E apolipoprotein polymorphism appeared greater in female children than male.

CONCLUSIONS

The e4 allele was associated with higher levels of total cholesterol, LDL cholesterol and B-100 apolipoprotein and indicates the necessity of additional research into the interactions between polymorphism E apolipoprotein and other genes, life styles, risk factors and potential contribution to cardiovascular diseases.

Authors+Show Affiliations

Grupo de Nutrición, Subdirección de Investigación, Instituto Nacional de Salud, Bogotá, DC, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

18320120

Citation

Callas, Ney, et al. "[Genetic Polymorphism of the E Apolipoprotein in School Age Children: Comparison With Levels of Plasma Lipids and Apolipoproteins]." Biomedica : Revista Del Instituto Nacional De Salud, vol. 27, no. 4, 2007, pp. 526-36.
Callas N, Poveda E, Baracaldo C, et al. [Genetic polymorphism of the E apolipoprotein in school age children: comparison with levels of plasma lipids and apolipoproteins]. Biomedica. 2007;27(4):526-36.
Callas, N., Poveda, E., Baracaldo, C., Hernández, P., Castillo, C., & Guerra, M. (2007). [Genetic polymorphism of the E apolipoprotein in school age children: comparison with levels of plasma lipids and apolipoproteins]. Biomedica : Revista Del Instituto Nacional De Salud, 27(4), 526-36.
Callas N, et al. [Genetic Polymorphism of the E Apolipoprotein in School Age Children: Comparison With Levels of Plasma Lipids and Apolipoproteins]. Biomedica. 2007;27(4):526-36. PubMed PMID: 18320120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic polymorphism of the E apolipoprotein in school age children: comparison with levels of plasma lipids and apolipoproteins]. AU - Callas,Ney, AU - Poveda,Elpidia, AU - Baracaldo,César, AU - Hernández,Patricia, AU - Castillo,Carlina, AU - Guerra,Martha, PY - 2007/03/05/received PY - 2007/08/23/accepted PY - 2008/3/6/pubmed PY - 2008/5/20/medline PY - 2008/3/6/entrez SP - 526 EP - 36 JF - Biomedica : revista del Instituto Nacional de Salud JO - Biomedica VL - 27 IS - 4 N2 - INTRODUCTION: Research in laboratories around the world has documented the contribution of the E apolipoprotein alleles to structural variations of lipids and apolipoproteins. OBJECTIVE: The gene frequencies of the E apolipoprotein alleles were compared with the lipid and apolipoprotein levels in school age children. MATERIALS AND METHODS: Six hundred and ninety one 5 to 15 years old school age children from the Colombian departments of Cundinamarca, Boyacá, Meta, Santander and Norte de Santander, were evaluated. The genotypes of the E apolipoprotein were identified by polymerase chain reaction-restriction fragment length polymorphism. Plasma levels for the following 5 lipids and lipoproteins were assayed: total cholesterol, HDL (high density lipoprotein) cholesterol, LDL (low density lipoprotein) cholesterol, triglycerides, VLDL (very low density lipoprotein) cholesterol, A-I apolipoprotein and B-100 apolipoprotein. RESULTS: Alleles e2, e3 and e4 were found in frequencies of 0.04, 0.86 and 0.08, respectively. The E4 group (E4/3-E4/4), in contrast with the E2 group (E3/2-E2/2), presented highest plasma concentrations of total cholesterol, LDL cholesterol and B-100 apolipoprotein (p=0.014, 0.001 and 0.000, respectively). When the E3/3 group was compared with E2, the same result was obtained (p=0.015, 0.002 and 0.002, respectively). The influence of the E apolipoprotein polymorphism appeared greater in female children than male. CONCLUSIONS: The e4 allele was associated with higher levels of total cholesterol, LDL cholesterol and B-100 apolipoprotein and indicates the necessity of additional research into the interactions between polymorphism E apolipoprotein and other genes, life styles, risk factors and potential contribution to cardiovascular diseases. SN - 0120-4157 UR - https://www.unboundmedicine.com/medline/citation/18320120/[Genetic_polymorphism_of_the_E_apolipoprotein_in_school_age_children:_comparison_with_levels_of_plasma_lipids_and_apolipoproteins]_ DB - PRIME DP - Unbound Medicine ER -