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Allergies to sulfonamide antibiotics and sulfur-containing drugs.
Ann Allergy Asthma Immunol. 2008 Feb; 100(2):91-100; quiz 100-3, 111.AA

Abstract

OBJECTIVE

To provide a literature review and clinical summary of the evaluation and management of sulfonamide drug reactions.

DATA SOURCES

Published English-language medical literature.

STUDY SELECTION

Selected trials of drug desensitization protocols.

RESULTS

Obtaining a detailed history is invaluable in assessing a history of reactions to sulfonamide medications, because allergy to these drugs remains a clinical diagnosis at present. Numerous efficacious drug desensitization protocols for management have been published and are reviewed in detail.

CONCLUSIONS

The term sulfa allergy is imprecise and misleading and therefore should be discouraged. There are important distinctions between sulfonylarylamines (antimicrobial sulfonamides), nonarylamine (nonantimicrobial) sulfonamides, and sulfones, with regard to allergic and other adverse drug reactions. Most reactions to sulfonylarylamines probably result from multifactorial immunologic and toxic metabolic mechanisms, whereas less is known about the precise mechanisms of reactions to other sulfur-containing drugs.

Authors+Show Affiliations

Allergy Clinic, LLC, Portland, Oregon 97205, USA. d.dibbern@verizon.netNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18320910

Citation

Dibbern, Donald A., and Anthony Montanaro. "Allergies to Sulfonamide Antibiotics and Sulfur-containing Drugs." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 100, no. 2, 2008, pp. 91-100; quiz 100-3, 111.
Dibbern DA, Montanaro A. Allergies to sulfonamide antibiotics and sulfur-containing drugs. Ann Allergy Asthma Immunol. 2008;100(2):91-100; quiz 100-3, 111.
Dibbern, D. A., & Montanaro, A. (2008). Allergies to sulfonamide antibiotics and sulfur-containing drugs. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 100(2), 91-100; quiz 100-3, 111. https://doi.org/10.1016/S1081-1206(10)60415-2
Dibbern DA, Montanaro A. Allergies to Sulfonamide Antibiotics and Sulfur-containing Drugs. Ann Allergy Asthma Immunol. 2008;100(2):91-100; quiz 100-3, 111. PubMed PMID: 18320910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergies to sulfonamide antibiotics and sulfur-containing drugs. AU - Dibbern,Donald A,Jr AU - Montanaro,Anthony, PY - 2008/3/7/pubmed PY - 2008/3/28/medline PY - 2008/3/7/entrez SP - 91-100; quiz 100-3, 111 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 100 IS - 2 N2 - OBJECTIVE: To provide a literature review and clinical summary of the evaluation and management of sulfonamide drug reactions. DATA SOURCES: Published English-language medical literature. STUDY SELECTION: Selected trials of drug desensitization protocols. RESULTS: Obtaining a detailed history is invaluable in assessing a history of reactions to sulfonamide medications, because allergy to these drugs remains a clinical diagnosis at present. Numerous efficacious drug desensitization protocols for management have been published and are reviewed in detail. CONCLUSIONS: The term sulfa allergy is imprecise and misleading and therefore should be discouraged. There are important distinctions between sulfonylarylamines (antimicrobial sulfonamides), nonarylamine (nonantimicrobial) sulfonamides, and sulfones, with regard to allergic and other adverse drug reactions. Most reactions to sulfonylarylamines probably result from multifactorial immunologic and toxic metabolic mechanisms, whereas less is known about the precise mechanisms of reactions to other sulfur-containing drugs. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/18320910/Allergies_to_sulfonamide_antibiotics_and_sulfur_containing_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60415-2 DB - PRIME DP - Unbound Medicine ER -