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Extracellular matrix components and regulators in the airway smooth muscle in asthma.
Eur Respir J. 2008 Jul; 32(1):61-9.ER

Abstract

There is an intimate relationship between the extracellular matrix (ECM) and smooth muscle cells within the airways. Few studies have comprehensively assessed the composition of different ECM components and its regulators within the airway smooth muscle (ASM) in asthma. With the aid of image analysis, the fractional areas of total collagen and elastic fibres were quantified within the ASM of 35 subjects with fatal asthma (FA) and compared with 10 nonfatal asthma (NFA) patients and 22 nonasthmatic control cases. Expression of collagen I and III, fibronectin, versican, matrix metalloproteinase (MMP)-1, -2, -9 and -12 and tissue inhibitor of metalloproteinase-1 and -2 was quantified within the ASM in 22 FA and 10 control cases. In the large airways of FA cases, the fractional area of elastic fibres within the ASM was increased compared with NFA and controls. Similarly, fibronectin, MMP-9 and MMP-12 were increased within the ASM in large airways of FA cases compared with controls. Elastic fibres were increased in small airways in FA only in comparison with NFA cases. There is altered extracellular matrix composition and a degradative environment within the airway smooth muscle in fatal asthma patients, which may have important consequences for the mechanical and synthetic functions of airway smooth muscle.

Authors+Show Affiliations

Dept of Pathology, São Paulo University Medical School, Avenida Dr Arnaldo, 455, 01246-903, São Paulo SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18321931

Citation

Araujo, B B., et al. "Extracellular Matrix Components and Regulators in the Airway Smooth Muscle in Asthma." The European Respiratory Journal, vol. 32, no. 1, 2008, pp. 61-9.
Araujo BB, Dolhnikoff M, Silva LF, et al. Extracellular matrix components and regulators in the airway smooth muscle in asthma. Eur Respir J. 2008;32(1):61-9.
Araujo, B. B., Dolhnikoff, M., Silva, L. F., Elliot, J., Lindeman, J. H., Ferreira, D. S., Mulder, A., Gomes, H. A., Fernezlian, S. M., James, A., & Mauad, T. (2008). Extracellular matrix components and regulators in the airway smooth muscle in asthma. The European Respiratory Journal, 32(1), 61-9. https://doi.org/10.1183/09031936.00147807
Araujo BB, et al. Extracellular Matrix Components and Regulators in the Airway Smooth Muscle in Asthma. Eur Respir J. 2008;32(1):61-9. PubMed PMID: 18321931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracellular matrix components and regulators in the airway smooth muscle in asthma. AU - Araujo,B B, AU - Dolhnikoff,M, AU - Silva,L F F, AU - Elliot,J, AU - Lindeman,J H N, AU - Ferreira,D S, AU - Mulder,A, AU - Gomes,H A P, AU - Fernezlian,S M, AU - James,A, AU - Mauad,T, Y1 - 2008/03/05/ PY - 2008/3/7/pubmed PY - 2008/10/2/medline PY - 2008/3/7/entrez SP - 61 EP - 9 JF - The European respiratory journal JO - Eur Respir J VL - 32 IS - 1 N2 - There is an intimate relationship between the extracellular matrix (ECM) and smooth muscle cells within the airways. Few studies have comprehensively assessed the composition of different ECM components and its regulators within the airway smooth muscle (ASM) in asthma. With the aid of image analysis, the fractional areas of total collagen and elastic fibres were quantified within the ASM of 35 subjects with fatal asthma (FA) and compared with 10 nonfatal asthma (NFA) patients and 22 nonasthmatic control cases. Expression of collagen I and III, fibronectin, versican, matrix metalloproteinase (MMP)-1, -2, -9 and -12 and tissue inhibitor of metalloproteinase-1 and -2 was quantified within the ASM in 22 FA and 10 control cases. In the large airways of FA cases, the fractional area of elastic fibres within the ASM was increased compared with NFA and controls. Similarly, fibronectin, MMP-9 and MMP-12 were increased within the ASM in large airways of FA cases compared with controls. Elastic fibres were increased in small airways in FA only in comparison with NFA cases. There is altered extracellular matrix composition and a degradative environment within the airway smooth muscle in fatal asthma patients, which may have important consequences for the mechanical and synthetic functions of airway smooth muscle. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/18321931/Extracellular_matrix_components_and_regulators_in_the_airway_smooth_muscle_in_asthma_ DB - PRIME DP - Unbound Medicine ER -