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Prevalence of cysts in seminal tract and abnormal semen parameters in patients with autosomal dominant polycystic kidney disease.
Clin J Am Soc Nephrol. 2008 May; 3(3):790-3.CJ

Abstract

BACKGROUND AND OBJECTIVES

Autosomal dominant polycystic kidney disease is a systemic disorder with a wide range of extrarenal involvement. The scope of this study was to analyze the prevalence of seminal cysts and to correlate these findings with the sperm parameters in patients with autosomal dominant polycystic kidney disease.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

A prospective study enrolled 30 adult men with autosomal dominant polycystic kidney disease. Of these 30 patients, 22 agreed to provide a semen sample for analysis, and 28 of 30 agreed to undergo an ultrasound rectal examination. Data obtained from the semen tests and from the ultrasound study were compared.

RESULTS

Cysts in the seminal tract were present in 10 (43.47%) of 28 individuals. Twenty of 22 patients showed abnormal semen parameters, with asthenozoospermia as the most common finding. No correlation between ultrasound findings and sperm abnormalities was observed.

CONCLUSIONS

The presence of cysts in the seminal tract is remarkably high (43.47%); however, this finding does not correlate with sperm abnormalities, which are also a frequent finding, especially asthenozoospermia. This semen abnormality is probably related to the abnormal function of polycystins. More attention should be paid to reproductive aspects in the initial evaluation of patients with autosomal dominant polycystic kidney disease before their ability to conceive is further impaired by uremia.

Authors+Show Affiliations

Inherited Renal Disorders, Nephrology Department, Fundació Puigvert, Cartagena 340-350, 08025 Barcelona, Spain. rtorra@fundacio-puigvert.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18322042

Citation

Torra, Roser, et al. "Prevalence of Cysts in Seminal Tract and Abnormal Semen Parameters in Patients With Autosomal Dominant Polycystic Kidney Disease." Clinical Journal of the American Society of Nephrology : CJASN, vol. 3, no. 3, 2008, pp. 790-3.
Torra R, Sarquella J, Calabia J, et al. Prevalence of cysts in seminal tract and abnormal semen parameters in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2008;3(3):790-3.
Torra, R., Sarquella, J., Calabia, J., Martí, J., Ars, E., Fernández-Llama, P., & Ballarin, J. (2008). Prevalence of cysts in seminal tract and abnormal semen parameters in patients with autosomal dominant polycystic kidney disease. Clinical Journal of the American Society of Nephrology : CJASN, 3(3), 790-3. https://doi.org/10.2215/CJN.05311107
Torra R, et al. Prevalence of Cysts in Seminal Tract and Abnormal Semen Parameters in Patients With Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2008;3(3):790-3. PubMed PMID: 18322042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of cysts in seminal tract and abnormal semen parameters in patients with autosomal dominant polycystic kidney disease. AU - Torra,Roser, AU - Sarquella,Joaquim, AU - Calabia,Jordi, AU - Martí,Jordi, AU - Ars,Elisabet, AU - Fernández-Llama,Patricia, AU - Ballarin,Jose, Y1 - 2008/03/05/ PY - 2008/3/7/pubmed PY - 2008/6/6/medline PY - 2008/3/7/entrez SP - 790 EP - 3 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 3 IS - 3 N2 - BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is a systemic disorder with a wide range of extrarenal involvement. The scope of this study was to analyze the prevalence of seminal cysts and to correlate these findings with the sperm parameters in patients with autosomal dominant polycystic kidney disease. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A prospective study enrolled 30 adult men with autosomal dominant polycystic kidney disease. Of these 30 patients, 22 agreed to provide a semen sample for analysis, and 28 of 30 agreed to undergo an ultrasound rectal examination. Data obtained from the semen tests and from the ultrasound study were compared. RESULTS: Cysts in the seminal tract were present in 10 (43.47%) of 28 individuals. Twenty of 22 patients showed abnormal semen parameters, with asthenozoospermia as the most common finding. No correlation between ultrasound findings and sperm abnormalities was observed. CONCLUSIONS: The presence of cysts in the seminal tract is remarkably high (43.47%); however, this finding does not correlate with sperm abnormalities, which are also a frequent finding, especially asthenozoospermia. This semen abnormality is probably related to the abnormal function of polycystins. More attention should be paid to reproductive aspects in the initial evaluation of patients with autosomal dominant polycystic kidney disease before their ability to conceive is further impaired by uremia. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/18322042/Prevalence_of_cysts_in_seminal_tract_and_abnormal_semen_parameters_in_patients_with_autosomal_dominant_polycystic_kidney_disease_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=18322042 DB - PRIME DP - Unbound Medicine ER -