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Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis.
Iran J Allergy Asthma Immunol. 2008 Mar; 7(1):19-24.IJ

Abstract

The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important to know whether certain subtypes show any preferential association with AS. Because there is no report regarding HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present study was to assess the frequency of subtypes of human leukocyte antigen (HLA)-B27 in patients with ankylosing spondylitis in Iranian populationOne hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative) were selected for this study. HLA-B27 positive patients were screened by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP) for B*27 subtyping.The results of present study revealed that only two subtypes were detected in Iranian patients, including B*2705 (52 patients, 63.4%) and B*2702 (30 patients, 36.6%). Our results showed a restricted number of HLA-B27 subtypes associated with AS in Iran and an elevated frequency of the B*2705 allele in these patients similar to other Euro-Caucasoid (Aryan) groups in the world.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nicknam MH
Molecular Immunology Research Center, Faculty of Medicine, Medical Sciences/ University of Tehran, Tehran, Iran. nicknam_m@yahoo.com
Mahmoudi M
No affiliation info available
Amirzargar AA
No affiliation info available
Ganjalikhani Hakemi M
No affiliation info available
Khosravi F
No affiliation info available
Jamshidi AR
No affiliation info available
Amirkhani A
No affiliation info available
Ansaripour B
No affiliation info available
Pourpak Z
No affiliation info available
Moin M
No affiliation info available
Nikbin B
No affiliation info available

MeSH

AdolescentAdultFemaleGene FrequencyGenetic Predisposition to DiseaseHLA-B AntigensHLA-B27 AntigenHumansIranMaleMiddle AgedPolymorphism, GeneticSpondylitis, Ankylosing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18322308

Citation

Nicknam, Mohamad Hossein, et al. "Determination of HLA-B27 Subtypes in Iranian Patients With Ankylosing Spondylitis." Iranian Journal of Allergy, Asthma, and Immunology, vol. 7, no. 1, 2008, pp. 19-24.
Nicknam MH, Mahmoudi M, Amirzargar AA, et al. Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis. Iran J Allergy Asthma Immunol. 2008;7(1):19-24.
Nicknam, M. H., Mahmoudi, M., Amirzargar, A. A., Ganjalikhani Hakemi, M., Khosravi, F., Jamshidi, A. R., Amirkhani, A., Ansaripour, B., Pourpak, Z., Moin, M., & Nikbin, B. (2008). Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis. Iranian Journal of Allergy, Asthma, and Immunology, 7(1), 19-24. https://doi.org/07.01/ijaai.1924
Nicknam MH, et al. Determination of HLA-B27 Subtypes in Iranian Patients With Ankylosing Spondylitis. Iran J Allergy Asthma Immunol. 2008;7(1):19-24. PubMed PMID: 18322308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis. AU - Nicknam,Mohamad Hossein, AU - Mahmoudi,Mahdi, AU - Amirzargar,Ali Akbar, AU - Ganjalikhani Hakemi,Mazdak, AU - Khosravi,Farideh, AU - Jamshidi,Ahmad Reza, AU - Amirkhani,Aref, AU - Ansaripour,Bita, AU - Pourpak,Zahra, AU - Moin,Mostafa, AU - Nikbin,Behrooz, PY - 2008/3/7/pubmed PY - 2009/1/30/medline PY - 2008/3/7/entrez SP - 19 EP - 24 JF - Iranian journal of allergy, asthma, and immunology JO - Iran J Allergy Asthma Immunol VL - 7 IS - 1 N2 - The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important to know whether certain subtypes show any preferential association with AS. Because there is no report regarding HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present study was to assess the frequency of subtypes of human leukocyte antigen (HLA)-B27 in patients with ankylosing spondylitis in Iranian populationOne hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative) were selected for this study. HLA-B27 positive patients were screened by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP) for B*27 subtyping.The results of present study revealed that only two subtypes were detected in Iranian patients, including B*2705 (52 patients, 63.4%) and B*2702 (30 patients, 36.6%). Our results showed a restricted number of HLA-B27 subtypes associated with AS in Iran and an elevated frequency of the B*2705 allele in these patients similar to other Euro-Caucasoid (Aryan) groups in the world. SN - 1735-1502 UR - https://www.unboundmedicine.com/medline/citation/18322308/Determination_of_HLA_B27_subtypes_in_Iranian_patients_with_ankylosing_spondylitis_ DB - PRIME DP - Unbound Medicine ER -