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Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex.
Iran J Allergy Asthma Immunol. 2008 Mar; 7(1):31-6.IJ

Abstract

Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD).Genetic susceptibility for autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in Iran. We have therefore investigated the prevalence of anti-thyroid peroxidase (anti-TPO) and anti thyroglubolin (Anti TG) antibodies in type 1 diabetic patients, and compared the effect of age and sex on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Iran.Ninety one subjects with type 1 diabetes mellitus and one hundred and sixty three unrelated normal controls under the age of thirty years were recruited for the detection of anti-TPO and anti-TG. Radio Immuno Assay and chemiluminescence methods were used for anti-TPO and anti-TG detection respectively.Among 91 type 1 diabetic patients, 36 (39.6%) were positive for anti-TPO and 27(30%) were positive for antiTG. Anti-TPO antibodies were detected only in 6.7% of control group. Comparing with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female: male, 28:14 vs. 28:20 respectively). Among the type 1 diabetic patients those with thyroid autoimmunity, tended to be older (p: 0.04) and to have higher TSH concentration (p: 0.03). Patients with high anti-TPO levels had longer duration of diabetes (P: 0.02).The presence of anti-TPO in 39.6% of our type 1 diabetic patients comparing with 8.5% of normal subjects confirmed the strong association of ATD and type 1 diabetes mellitus.

Authors+Show Affiliations

Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. faranaksharifi@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18322310

Citation

Sharifi, Faranak, et al. "Thyroid Function and Anti-thyroid Antibodies in Iranian Patients With Type 1 Diabetes Mellitus: Influences of Age and Sex." Iranian Journal of Allergy, Asthma, and Immunology, vol. 7, no. 1, 2008, pp. 31-6.
Sharifi F, Ghasemi L, Mousavinasab N. Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex. Iran J Allergy Asthma Immunol. 2008;7(1):31-6.
Sharifi, F., Ghasemi, L., & Mousavinasab, N. (2008). Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex. Iranian Journal of Allergy, Asthma, and Immunology, 7(1), 31-6. https://doi.org/07.01/ijaai.3136
Sharifi F, Ghasemi L, Mousavinasab N. Thyroid Function and Anti-thyroid Antibodies in Iranian Patients With Type 1 Diabetes Mellitus: Influences of Age and Sex. Iran J Allergy Asthma Immunol. 2008;7(1):31-6. PubMed PMID: 18322310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid function and anti-thyroid antibodies in Iranian patients with type 1 diabetes mellitus: influences of age and sex. AU - Sharifi,Faranak, AU - Ghasemi,Leila, AU - Mousavinasab,Nouraddin, PY - 2008/3/7/pubmed PY - 2009/1/30/medline PY - 2008/3/7/entrez SP - 31 EP - 6 JF - Iranian journal of allergy, asthma, and immunology JO - Iran J Allergy Asthma Immunol VL - 7 IS - 1 N2 - Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD).Genetic susceptibility for autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in Iran. We have therefore investigated the prevalence of anti-thyroid peroxidase (anti-TPO) and anti thyroglubolin (Anti TG) antibodies in type 1 diabetic patients, and compared the effect of age and sex on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Iran.Ninety one subjects with type 1 diabetes mellitus and one hundred and sixty three unrelated normal controls under the age of thirty years were recruited for the detection of anti-TPO and anti-TG. Radio Immuno Assay and chemiluminescence methods were used for anti-TPO and anti-TG detection respectively.Among 91 type 1 diabetic patients, 36 (39.6%) were positive for anti-TPO and 27(30%) were positive for antiTG. Anti-TPO antibodies were detected only in 6.7% of control group. Comparing with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female: male, 28:14 vs. 28:20 respectively). Among the type 1 diabetic patients those with thyroid autoimmunity, tended to be older (p: 0.04) and to have higher TSH concentration (p: 0.03). Patients with high anti-TPO levels had longer duration of diabetes (P: 0.02).The presence of anti-TPO in 39.6% of our type 1 diabetic patients comparing with 8.5% of normal subjects confirmed the strong association of ATD and type 1 diabetes mellitus. SN - 1735-1502 UR - https://www.unboundmedicine.com/medline/citation/18322310/Thyroid_function_and_anti_thyroid_antibodies_in_Iranian_patients_with_type_1_diabetes_mellitus:_influences_of_age_and_sex_ L2 - http://ijaai.tums.ac.ir/index.php/ijaai/article/view/196 DB - PRIME DP - Unbound Medicine ER -