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Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial.
Am J Nephrol. 2008; 28(4):654-60.AJ

Abstract

AIMS

We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza).

METHODS

40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006-2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. >or=1:40), the serological response (i.e. >or=4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated.

RESULTS

KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination.

CONCLUSIONS

Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Keshtkar-Jahromi M
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University MC, Tehran, Iran. maryam_keshtkar@yahoo.com
Argani H
No affiliation info available
Rahnavardi M
No affiliation info available
Mirchi E
No affiliation info available
Atabak S
No affiliation info available
Tara SA
No affiliation info available
Gachkar L
No affiliation info available
Noori-Froothghe A
No affiliation info available
Mokhtari-Azad T
No affiliation info available

MeSH

AdultAntibodies, ViralAntibody FormationAzathioprineFemaleHumansImmunosuppressive AgentsInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesKidney TransplantationMaleMycophenolic AcidVaccination

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18322360

Citation

Keshtkar-Jahromi, Maryam, et al. "Antibody Response to Influenza Immunization in Kidney Transplant Recipients Receiving Either Azathioprine or Mycophenolate: a Controlled Trial." American Journal of Nephrology, vol. 28, no. 4, 2008, pp. 654-60.
Keshtkar-Jahromi M, Argani H, Rahnavardi M, et al. Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial. Am J Nephrol. 2008;28(4):654-60.
Keshtkar-Jahromi, M., Argani, H., Rahnavardi, M., Mirchi, E., Atabak, S., Tara, S. A., Gachkar, L., Noori-Froothghe, A., & Mokhtari-Azad, T. (2008). Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial. American Journal of Nephrology, 28(4), 654-60. https://doi.org/10.1159/000119742
Keshtkar-Jahromi M, et al. Antibody Response to Influenza Immunization in Kidney Transplant Recipients Receiving Either Azathioprine or Mycophenolate: a Controlled Trial. Am J Nephrol. 2008;28(4):654-60. PubMed PMID: 18322360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial. AU - Keshtkar-Jahromi,Maryam, AU - Argani,Hassan, AU - Rahnavardi,Mohammad, AU - Mirchi,Elham, AU - Atabak,Shahnaz, AU - Tara,Seied Ahmad, AU - Gachkar,Latif, AU - Noori-Froothghe,Azam, AU - Mokhtari-Azad,Talat, Y1 - 2008/03/06/ PY - 2007/08/26/received PY - 2008/01/17/accepted PY - 2008/3/7/pubmed PY - 2008/7/29/medline PY - 2008/3/7/entrez SP - 654 EP - 60 JF - American journal of nephrology JO - Am J Nephrol VL - 28 IS - 4 N2 - AIMS: We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). METHODS: 40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006-2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. >or=1:40), the serological response (i.e. >or=4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. RESULTS: KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. CONCLUSIONS: Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs. SN - 1421-9670 UR - https://www.unboundmedicine.com/medline/citation/18322360/Antibody_response_to_influenza_immunization_in_kidney_transplant_recipients_receiving_either_azathioprine_or_mycophenolate:_a_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -