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Basic research on dopamine in Parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness.
Neurodegener Dis. 2008; 5(3-4):114-7.ND

Abstract

The article recapitulates some of the historical facts that led up to the recognition of dopamine (DA) as a biologically active substance in the brain and its crucial role in Parkinson's disease (PD). Three events to which the writer has been an eyewitness are specially highlighted and placed in their proper historical perspective: (1) the discovery of the striatal DA deficit in the PD brain; (2) the development of the DA replacement treatment with L-dopa, and (3) the 'birth' of the nigrostriatal DA pathway. The opposition to the new observations and their unexpected and far-reaching consequences will be illustrated by briefly discussing the strongly negative opinions expressed by some famous brain scientists of the day about the relationship between the substantia nigra, PD, and the DA-containing nigrostriatal fiber connection.

Authors+Show Affiliations

Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

18322366

Citation

Hornykiewicz, Oleh. "Basic Research On Dopamine in Parkinson's Disease and the Discovery of the Nigrostriatal Dopamine Pathway: the View of an Eyewitness." Neuro-degenerative Diseases, vol. 5, no. 3-4, 2008, pp. 114-7.
Hornykiewicz O. Basic research on dopamine in Parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness. Neurodegener Dis. 2008;5(3-4):114-7.
Hornykiewicz, O. (2008). Basic research on dopamine in Parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness. Neuro-degenerative Diseases, 5(3-4), 114-7. https://doi.org/10.1159/000113678
Hornykiewicz O. Basic Research On Dopamine in Parkinson's Disease and the Discovery of the Nigrostriatal Dopamine Pathway: the View of an Eyewitness. Neurodegener Dis. 2008;5(3-4):114-7. PubMed PMID: 18322366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basic research on dopamine in Parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness. A1 - Hornykiewicz,Oleh, Y1 - 2008/03/06/ PY - 2008/3/7/pubmed PY - 2008/5/16/medline PY - 2008/3/7/entrez SP - 114 EP - 7 JF - Neuro-degenerative diseases JO - Neurodegener Dis VL - 5 IS - 3-4 N2 - The article recapitulates some of the historical facts that led up to the recognition of dopamine (DA) as a biologically active substance in the brain and its crucial role in Parkinson's disease (PD). Three events to which the writer has been an eyewitness are specially highlighted and placed in their proper historical perspective: (1) the discovery of the striatal DA deficit in the PD brain; (2) the development of the DA replacement treatment with L-dopa, and (3) the 'birth' of the nigrostriatal DA pathway. The opposition to the new observations and their unexpected and far-reaching consequences will be illustrated by briefly discussing the strongly negative opinions expressed by some famous brain scientists of the day about the relationship between the substantia nigra, PD, and the DA-containing nigrostriatal fiber connection. SN - 1660-2862 UR - https://www.unboundmedicine.com/medline/citation/18322366/Basic_research_on_dopamine_in_Parkinson's_disease_and_the_discovery_of_the_nigrostriatal_dopamine_pathway:_the_view_of_an_eyewitness_ L2 - https://www.karger.com?DOI=10.1159/000113678 DB - PRIME DP - Unbound Medicine ER -