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Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model.
Neurodegener Dis 2008; 5(3-4):140-2ND

Abstract

Accumulating evidence points to an important role of intraneuronal beta-amyloid (Abeta) in the development of Alzheimer's disease (AD), with its typical clinical symptoms like memory impairment and changes in personality. We have previously reported on the Abeta precursor protein and presenilin-1 knock-out (APP/PS1KI) mouse model with abundant intraneuronal Abeta(42) accumulation and a 50% loss of CA1 neurons at 10 months of age. In addition, we observed reduced short- and long-term synaptic plasticity, hippocampal neuron loss, and reduced performance in a working memory task. These observations support a pivotal role of intraneuronal Abeta accumulation as a principal pathological trigger in AD.

Authors+Show Affiliations

Department of Psychiatry, Division of Molecular Psychiatry, University of Goettingen, Goettingen, Germany. tbayer@gwdg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18322372

Citation

Bayer, Thomas A., et al. "Intraneuronal Beta-amyloid Is a Major Risk Factor--novel Evidence From the APP/PS1KI Mouse Model." Neuro-degenerative Diseases, vol. 5, no. 3-4, 2008, pp. 140-2.
Bayer TA, Breyhan H, Duan K, et al. Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model. Neurodegener Dis. 2008;5(3-4):140-2.
Bayer, T. A., Breyhan, H., Duan, K., Rettig, J., & Wirths, O. (2008). Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model. Neuro-degenerative Diseases, 5(3-4), pp. 140-2. doi:10.1159/000113684.
Bayer TA, et al. Intraneuronal Beta-amyloid Is a Major Risk Factor--novel Evidence From the APP/PS1KI Mouse Model. Neurodegener Dis. 2008;5(3-4):140-2. PubMed PMID: 18322372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model. AU - Bayer,Thomas A, AU - Breyhan,Henning, AU - Duan,Kailai, AU - Rettig,Jens, AU - Wirths,Oliver, Y1 - 2008/03/06/ PY - 2008/3/7/pubmed PY - 2008/5/16/medline PY - 2008/3/7/entrez SP - 140 EP - 2 JF - Neuro-degenerative diseases JO - Neurodegener Dis VL - 5 IS - 3-4 N2 - Accumulating evidence points to an important role of intraneuronal beta-amyloid (Abeta) in the development of Alzheimer's disease (AD), with its typical clinical symptoms like memory impairment and changes in personality. We have previously reported on the Abeta precursor protein and presenilin-1 knock-out (APP/PS1KI) mouse model with abundant intraneuronal Abeta(42) accumulation and a 50% loss of CA1 neurons at 10 months of age. In addition, we observed reduced short- and long-term synaptic plasticity, hippocampal neuron loss, and reduced performance in a working memory task. These observations support a pivotal role of intraneuronal Abeta accumulation as a principal pathological trigger in AD. SN - 1660-2862 UR - https://www.unboundmedicine.com/medline/citation/18322372/Intraneuronal_beta_amyloid_is_a_major_risk_factor__novel_evidence_from_the_APP/PS1KI_mouse_model_ L2 - https://www.karger.com?DOI=10.1159/000113684 DB - PRIME DP - Unbound Medicine ER -