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[CD4+CD25+high regulatory T cells in patients with autoimmune hepatitis].

Abstract

OBJECTIVE

To investigate the role of CD4+CD25+high regulatory T cells in the pathogenesis of autoimmune hepatitis.

METHODS

CD4+CD25+ high regulatory T cells and CD4+ T cells were measured by using flow cytometry in 16 patients with autoimmune hepatitis, 22 patients with chronic hepatitis B and 20 healthy blood donors. Foxp3 protein was detected by immunohistochemical assay in liver tissues from the patients with autoimmune hepatitis or chronic hepatitis B.

RESULTS

The percentage of CD4+CD25+high/CD4+ in patients with autoimmune hepatitis was significantly lower than that in healthy controls and patients with chronic hepatitis B. Meanwhile, the percentage of CD4+CD25+high/CD4+ highly increased in patients with chronic hepatitis B, compared with healthy controls; Foxp3 positive cells were mostly located in the hepatic lobular perisinusoidal spaces and the portal tract, and there was a significant difference in the quantity of Foxp3 positive cells between patients with autoimmune hepatitis and chronic hepatitis B.

CONCLUSION

Patients with autoimmune hepatitis harbor a decreased percentage of CD4+CD25+ high regulatory T cells, which may be associated with development of autoimmunity.

Authors+Show Affiliations

Department of Pathogenic Biology, Suzhou University, Suzhou 215007, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18322595

Citation

Li, Ming, et al. "[CD4+CD25+high Regulatory T Cells in Patients With Autoimmune Hepatitis]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, vol. 21, no. 4, 2007, pp. 337-9.
Li M, Zhuge HX, Zhu CW, et al. [CD4+CD25+high regulatory T cells in patients with autoimmune hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007;21(4):337-9.
Li, M., Zhuge, H. X., Zhu, C. W., Xu, P., Iuo, X. R., Ye, J. Z., Zhu, W., Qian, F., & Wang, H. Y. (2007). [CD4+CD25+high regulatory T cells in patients with autoimmune hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, 21(4), 337-9.
Li M, et al. [CD4+CD25+high Regulatory T Cells in Patients With Autoimmune Hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007;21(4):337-9. PubMed PMID: 18322595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [CD4+CD25+high regulatory T cells in patients with autoimmune hepatitis]. AU - Li,Ming, AU - Zhuge,Hong-xiang, AU - Zhu,Chuan-wu, AU - Xu,Ping, AU - Iuo,Xiang-rong, AU - Ye,Jian-zhong, AU - Zhu,Wei, AU - Qian,Feng, AU - Wang,Hai-yan, PY - 2008/3/7/pubmed PY - 2009/5/6/medline PY - 2008/3/7/entrez SP - 337 EP - 9 JF - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology JO - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi VL - 21 IS - 4 N2 - OBJECTIVE: To investigate the role of CD4+CD25+high regulatory T cells in the pathogenesis of autoimmune hepatitis. METHODS: CD4+CD25+ high regulatory T cells and CD4+ T cells were measured by using flow cytometry in 16 patients with autoimmune hepatitis, 22 patients with chronic hepatitis B and 20 healthy blood donors. Foxp3 protein was detected by immunohistochemical assay in liver tissues from the patients with autoimmune hepatitis or chronic hepatitis B. RESULTS: The percentage of CD4+CD25+high/CD4+ in patients with autoimmune hepatitis was significantly lower than that in healthy controls and patients with chronic hepatitis B. Meanwhile, the percentage of CD4+CD25+high/CD4+ highly increased in patients with chronic hepatitis B, compared with healthy controls; Foxp3 positive cells were mostly located in the hepatic lobular perisinusoidal spaces and the portal tract, and there was a significant difference in the quantity of Foxp3 positive cells between patients with autoimmune hepatitis and chronic hepatitis B. CONCLUSION: Patients with autoimmune hepatitis harbor a decreased percentage of CD4+CD25+ high regulatory T cells, which may be associated with development of autoimmunity. SN - 1003-9279 UR - https://www.unboundmedicine.com/medline/citation/18322595/[CD4+CD25+high_regulatory_T_cells_in_patients_with_autoimmune_hepatitis]_ L2 - http://www.diseaseinfosearch.org/result/678 DB - PRIME DP - Unbound Medicine ER -