Tags

Type your tag names separated by a space and hit enter

A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International.
Int J Clin Pract. 2008 Apr; 62(4):575-84.IJ

Abstract

OBJECTIVES

To compare alendronate 70 mg once weekly (OW) with risedronate 35 mg OW with respect to change in bone mineral density (BMD), biochemical markers and upper gastrointestinal (UGI) tolerability over 24 months.

METHODS

This was a 12-month extension to the Fosamax Actonel Comparison Trial international study (FACTS). Postmenopausal women with osteoporosis randomly assigned to either alendronate 70 mg OW or risedronate 35 mg OW for the 12-month base study continued taking the same double-blind study medication. Efficacy measurements were BMD at the hip trochanter, lumbar spine, total hip, and femoral neck and levels of four bone turnover markers at 24 months. The primary hypothesis was that alendronate would produce a greater mean per cent increase from baseline in hip trochanter BMD at 24 months.

RESULTS

Trochanter BMD increased significantly from baseline to month 24 in both groups, with a significantly larger increase with alendronate: adjusted mean treatment difference of 1.50% (95% confidence interval: 0.74%, 2.26%; p < 0.001). Similar results were seen at all BMD sites. Significant geometric mean per cent decreases (p < 0.001) from baseline were seen for all four bone turnover markers in both groups, with significantly larger decreases (p < 0.001) with alendronate: adjusted mean treatment differences ranged from 8.9% to 25.3%. No significant differences were seen in incidence of UGI or other adverse events.

CONCLUSIONS

Alendronate 70 mg OW yielded significantly greater BMD gains and larger decreases in bone turnover marker levels than risedronate 35 mg OW over 24 months, with no difference in UGI tolerability.

Authors+Show Affiliations

Department of Medicine & Therapeutics, University of Aberdeen, Aberdeen, UK. d.m.reid@abdn.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18324951

Citation

Reid, D M., et al. "A Comparison of the Effect of Alendronate and Risedronate On Bone Mineral Density in Postmenopausal Women With Osteoporosis: 24-month Results From FACTS-International." International Journal of Clinical Practice, vol. 62, no. 4, 2008, pp. 575-84.
Reid DM, Hosking D, Kendler D, et al. A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International. Int J Clin Pract. 2008;62(4):575-84.
Reid, D. M., Hosking, D., Kendler, D., Brandi, M. L., Wark, J. D., Marques-Neto, J. F., Weryha, G., Verbruggen, N., Hustad, C. M., Mahlis, E. M., & Melton, M. E. (2008). A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International. International Journal of Clinical Practice, 62(4), 575-84. https://doi.org/10.1111/j.1742-1241.2008.01704.x
Reid DM, et al. A Comparison of the Effect of Alendronate and Risedronate On Bone Mineral Density in Postmenopausal Women With Osteoporosis: 24-month Results From FACTS-International. Int J Clin Pract. 2008;62(4):575-84. PubMed PMID: 18324951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International. AU - Reid,D M, AU - Hosking,D, AU - Kendler,D, AU - Brandi,M L, AU - Wark,J D, AU - Marques-Neto,J F, AU - Weryha,G, AU - Verbruggen,N, AU - Hustad,C M, AU - Mahlis,E M, AU - Melton,M E, PY - 2008/3/8/pubmed PY - 2008/8/1/medline PY - 2008/3/8/entrez SP - 575 EP - 84 JF - International journal of clinical practice JO - Int J Clin Pract VL - 62 IS - 4 N2 - OBJECTIVES: To compare alendronate 70 mg once weekly (OW) with risedronate 35 mg OW with respect to change in bone mineral density (BMD), biochemical markers and upper gastrointestinal (UGI) tolerability over 24 months. METHODS: This was a 12-month extension to the Fosamax Actonel Comparison Trial international study (FACTS). Postmenopausal women with osteoporosis randomly assigned to either alendronate 70 mg OW or risedronate 35 mg OW for the 12-month base study continued taking the same double-blind study medication. Efficacy measurements were BMD at the hip trochanter, lumbar spine, total hip, and femoral neck and levels of four bone turnover markers at 24 months. The primary hypothesis was that alendronate would produce a greater mean per cent increase from baseline in hip trochanter BMD at 24 months. RESULTS: Trochanter BMD increased significantly from baseline to month 24 in both groups, with a significantly larger increase with alendronate: adjusted mean treatment difference of 1.50% (95% confidence interval: 0.74%, 2.26%; p < 0.001). Similar results were seen at all BMD sites. Significant geometric mean per cent decreases (p < 0.001) from baseline were seen for all four bone turnover markers in both groups, with significantly larger decreases (p < 0.001) with alendronate: adjusted mean treatment differences ranged from 8.9% to 25.3%. No significant differences were seen in incidence of UGI or other adverse events. CONCLUSIONS: Alendronate 70 mg OW yielded significantly greater BMD gains and larger decreases in bone turnover marker levels than risedronate 35 mg OW over 24 months, with no difference in UGI tolerability. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/18324951/A_comparison_of_the_effect_of_alendronate_and_risedronate_on_bone_mineral_density_in_postmenopausal_women_with_osteoporosis:_24_month_results_from_FACTS_International_ L2 - https://doi.org/10.1111/j.1742-1241.2008.01704.x DB - PRIME DP - Unbound Medicine ER -