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Inappropriate gonadotropin secretion in polycystic ovary syndrome.
Fertil Steril. 2009 Apr; 91(4):1168-74.FS

Abstract

OBJECTIVE

To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS).

DESIGN

Retrospective study.

SETTING

Academic tertiary center.

PATIENT(S)

A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251).

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS.

RESULT(S)

The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects.

CONCLUSION(S)

The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Taipei Medical University-Wan Fang Medical Center, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

18325508

Citation

Hsu, Ming-I, et al. "Inappropriate Gonadotropin Secretion in Polycystic Ovary Syndrome." Fertility and Sterility, vol. 91, no. 4, 2009, pp. 1168-74.
Hsu MI, Liou TH, Liang SJ, et al. Inappropriate gonadotropin secretion in polycystic ovary syndrome. Fertil Steril. 2009;91(4):1168-74.
Hsu, M. I., Liou, T. H., Liang, S. J., Su, H. W., Wu, C. H., & Hsu, C. S. (2009). Inappropriate gonadotropin secretion in polycystic ovary syndrome. Fertility and Sterility, 91(4), 1168-74. https://doi.org/10.1016/j.fertnstert.2008.01.036
Hsu MI, et al. Inappropriate Gonadotropin Secretion in Polycystic Ovary Syndrome. Fertil Steril. 2009;91(4):1168-74. PubMed PMID: 18325508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inappropriate gonadotropin secretion in polycystic ovary syndrome. AU - Hsu,Ming-I, AU - Liou,Tsan-Hon, AU - Liang,So-Jung, AU - Su,Hung-Wen, AU - Wu,Chien-Hua, AU - Hsu,Chun-Sen, Y1 - 2008/03/05/ PY - 2007/09/24/received PY - 2008/01/08/revised PY - 2008/01/08/accepted PY - 2008/3/8/pubmed PY - 2009/5/2/medline PY - 2008/3/8/entrez SP - 1168 EP - 74 JF - Fertility and sterility JO - Fertil Steril VL - 91 IS - 4 N2 - OBJECTIVE: To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). DESIGN: Retrospective study. SETTING: Academic tertiary center. PATIENT(S): A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS. RESULT(S): The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects. CONCLUSION(S): The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18325508/Inappropriate_gonadotropin_secretion_in_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00043-5 DB - PRIME DP - Unbound Medicine ER -