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Plasmatic factors of haemostasis remain essentially unchanged except for PAI activity during n-3 fatty acid intake in type I diabetes mellitus.
Blood Coagul Fibrinolysis 1991; 2(2):259-65BC

Abstract

Diabetic patients are prone to develop vascular complications. Increased procoagulatory factors and a reduced fibrinolytic potential are considered as thrombogenic risk factors, although controversy remains. In epidemiological and dietary intervention studies fish or fish oil, rich in the two n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have demonstrated a potential to reduce cardiovascular disease. We compared the plasmatic coagulatory and fibrinolytic profile of 13 near normoglycaemic type I diabetics almost free of cardiovascular disease with healthy volunteers, matched for age and sex. Except for fibrinogen levels and tPA activity being elevated and soluble fibrin and fibrinopeptide A being reduced, no differences could be discerned between type I diabetics and controls in all investigated plasmatic parameters. In a dietary intervention study we investigated the effects of 5.4 g EPA and 2.7 g DHA per day during and after a 4-week dietary supplementation in the diabetic patients. The factors, inhibitors and activation products of coagulation and fibrinolysis measured were at best transiently affected by the diet. Only plasminogen activator inhibitory activity in plasma significantly increased during the dietary supplementation and returned to prediet values after cessation of n-3 fatty acids. Changes in PAI activity were negatively correlated to changes in serum triglycerides. We conclude that well adjusted type I diabetics show an almost unchanged haemostatic profile compared to matched healthy controls. A dietary intervention with n-3 fatty acids in these patients does not affect the plasmatic haemostatic pattern except for an increase in PAI activity.

Authors+Show Affiliations

Klinikum Innenstadt, Ludwig-Maximilians-Universität München, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1832569

Citation

Spannagl, M, et al. "Plasmatic Factors of Haemostasis Remain Essentially Unchanged Except for PAI Activity During N-3 Fatty Acid Intake in Type I Diabetes Mellitus." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 2, no. 2, 1991, pp. 259-65.
Spannagl M, Drummer C, Fröschl H, et al. Plasmatic factors of haemostasis remain essentially unchanged except for PAI activity during n-3 fatty acid intake in type I diabetes mellitus. Blood Coagul Fibrinolysis. 1991;2(2):259-65.
Spannagl, M., Drummer, C., Fröschl, H., von Schacky, C., Landgraf-Leurs, M. M., Landgraf, R., & Schramm, W. (1991). Plasmatic factors of haemostasis remain essentially unchanged except for PAI activity during n-3 fatty acid intake in type I diabetes mellitus. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 2(2), pp. 259-65.
Spannagl M, et al. Plasmatic Factors of Haemostasis Remain Essentially Unchanged Except for PAI Activity During N-3 Fatty Acid Intake in Type I Diabetes Mellitus. Blood Coagul Fibrinolysis. 1991;2(2):259-65. PubMed PMID: 1832569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasmatic factors of haemostasis remain essentially unchanged except for PAI activity during n-3 fatty acid intake in type I diabetes mellitus. AU - Spannagl,M, AU - Drummer,C, AU - Fröschl,H, AU - von Schacky,C, AU - Landgraf-Leurs,M M, AU - Landgraf,R, AU - Schramm,W, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 259 EP - 65 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 2 IS - 2 N2 - Diabetic patients are prone to develop vascular complications. Increased procoagulatory factors and a reduced fibrinolytic potential are considered as thrombogenic risk factors, although controversy remains. In epidemiological and dietary intervention studies fish or fish oil, rich in the two n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have demonstrated a potential to reduce cardiovascular disease. We compared the plasmatic coagulatory and fibrinolytic profile of 13 near normoglycaemic type I diabetics almost free of cardiovascular disease with healthy volunteers, matched for age and sex. Except for fibrinogen levels and tPA activity being elevated and soluble fibrin and fibrinopeptide A being reduced, no differences could be discerned between type I diabetics and controls in all investigated plasmatic parameters. In a dietary intervention study we investigated the effects of 5.4 g EPA and 2.7 g DHA per day during and after a 4-week dietary supplementation in the diabetic patients. The factors, inhibitors and activation products of coagulation and fibrinolysis measured were at best transiently affected by the diet. Only plasminogen activator inhibitory activity in plasma significantly increased during the dietary supplementation and returned to prediet values after cessation of n-3 fatty acids. Changes in PAI activity were negatively correlated to changes in serum triglycerides. We conclude that well adjusted type I diabetics show an almost unchanged haemostatic profile compared to matched healthy controls. A dietary intervention with n-3 fatty acids in these patients does not affect the plasmatic haemostatic pattern except for an increase in PAI activity. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/1832569/Plasmatic_factors_of_haemostasis_remain_essentially_unchanged_except_for_PAI_activity_during_n_3_fatty_acid_intake_in_type_I_diabetes_mellitus_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1832569.ui DB - PRIME DP - Unbound Medicine ER -