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Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre.
J Clin Pathol. 2008 Jun; 61(6):766-9.JC

Abstract

AIM

To evaluate the usefulness of vacuum assisted stereotactic guided mammotome biopsy in the diagnostic management of screen detected calcifications and to rationalise its use versus diagnostic excision.

METHODS

The first 100 mammotome biopsies preceded by a conventional needle core biopsy (NCB) were identified from the database of Leeds/Wakefield Breast Screening Service. The histological diagnosis on NCB and mammotome were reviewed and compared with the surgical histological diagnosis if excision had been performed.

RESULTS

Using mammotome, diagnoses were changed in 74 of the 100 cases. In 66 cases a definitive diagnosis (B2 or B5) was obtained. The incidence of inadequate/unsatisfactory (B1) biopsies was reduced from 36% to 9%. In 34 cases mammotome was not helpful in arriving at a definite diagnosis (B1/B3/B4). All cases diagnosed as malignant with mammotome were proven to have in situ or invasive malignancy on excision except for one case of ductal carcinoma in situ fully excised by mammotome. There was one false negative case of in-situ carcinoma with a prior benign (B2) mammotome diagnosis. Almost half the NCB uncertain (B3) cases required excision as the mammotome biopsies were also uncertain (B3). The majority were flat epithelial atypia and atypical intraductal proliferation.

CONCLUSIONS

Mammotome biopsy is particularly useful for further assessment of an inadequate (B1) or suspicious (B4) NCB diagnosis. Diagnostic surgical excision remains the method of choice for managing atypical/uncertain lesions (B3).

Authors+Show Affiliations

Department of Histopathology and Molecular Pathology, Leeds Teaching Hospitals, Leeds, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18326021

Citation

Kumaroswamy, V, et al. "Vacuum Assisted Stereotactic Guided Mammotome Biopsies in the Management of Screen Detected Microcalcifications: Experience of a Large Breast Screening Centre." Journal of Clinical Pathology, vol. 61, no. 6, 2008, pp. 766-9.
Kumaroswamy V, Liston J, Shaaban AM. Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre. J Clin Pathol. 2008;61(6):766-9.
Kumaroswamy, V., Liston, J., & Shaaban, A. M. (2008). Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre. Journal of Clinical Pathology, 61(6), 766-9. https://doi.org/10.1136/jcp.2007.054130
Kumaroswamy V, Liston J, Shaaban AM. Vacuum Assisted Stereotactic Guided Mammotome Biopsies in the Management of Screen Detected Microcalcifications: Experience of a Large Breast Screening Centre. J Clin Pathol. 2008;61(6):766-9. PubMed PMID: 18326021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre. AU - Kumaroswamy,V, AU - Liston,J, AU - Shaaban,A M, Y1 - 2008/03/06/ PY - 2008/3/8/pubmed PY - 2008/7/11/medline PY - 2008/3/8/entrez SP - 766 EP - 9 JF - Journal of clinical pathology JO - J Clin Pathol VL - 61 IS - 6 N2 - AIM: To evaluate the usefulness of vacuum assisted stereotactic guided mammotome biopsy in the diagnostic management of screen detected calcifications and to rationalise its use versus diagnostic excision. METHODS: The first 100 mammotome biopsies preceded by a conventional needle core biopsy (NCB) were identified from the database of Leeds/Wakefield Breast Screening Service. The histological diagnosis on NCB and mammotome were reviewed and compared with the surgical histological diagnosis if excision had been performed. RESULTS: Using mammotome, diagnoses were changed in 74 of the 100 cases. In 66 cases a definitive diagnosis (B2 or B5) was obtained. The incidence of inadequate/unsatisfactory (B1) biopsies was reduced from 36% to 9%. In 34 cases mammotome was not helpful in arriving at a definite diagnosis (B1/B3/B4). All cases diagnosed as malignant with mammotome were proven to have in situ or invasive malignancy on excision except for one case of ductal carcinoma in situ fully excised by mammotome. There was one false negative case of in-situ carcinoma with a prior benign (B2) mammotome diagnosis. Almost half the NCB uncertain (B3) cases required excision as the mammotome biopsies were also uncertain (B3). The majority were flat epithelial atypia and atypical intraductal proliferation. CONCLUSIONS: Mammotome biopsy is particularly useful for further assessment of an inadequate (B1) or suspicious (B4) NCB diagnosis. Diagnostic surgical excision remains the method of choice for managing atypical/uncertain lesions (B3). SN - 1472-4146 UR - https://www.unboundmedicine.com/medline/citation/18326021/Vacuum_assisted_stereotactic_guided_mammotome_biopsies_in_the_management_of_screen_detected_microcalcifications:_experience_of_a_large_breast_screening_centre_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&pmid=18326021 DB - PRIME DP - Unbound Medicine ER -