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Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease.

Abstract

BACKGROUND

The intake of trans fatty acids (TFA) from industrially hydrogenated vegetable oils (iTFA) is known to have a deleterious effect on cardiovascular health, the effects of TFA from ruminants (rTFA) are virtually unknown.

OBJECTIVE

The purpose of the present study was to compare the effects of rTFA and iTFA on plasma LDL concentrations and other cardiovascular disease risk factors in healthy subjects.

DESIGN

In a double-blind, randomized crossover controlled study, 38 healthy men were fed each of 4 experimental isoenergetic diets lasting 4 wk each. The 4 diets were high in rTFA (10.2 g/2500 kcal), moderate in rTFA (4.2 g/2500 kcal), high in iTFA (10.2 g/2500 kcal), and low in TFA from any source (2.2 g/2500 kcal) (control diet).

RESULTS

Plasma LDL-cholesterol concentrations were significantly higher after the high- rTFA diet than after the control (P = 0.03) or the moderate- rTFA (P = 0.002) diet. Plasma LDL-cholesterol concentrations also were significantly (P = 0.02) higher after the iTFA diet than after the moderate-rTFA diet. Plasma HDL-cholesterol concentrations were significantly (P = 0.02) lower after the high-rTFA diet than after the moderate-rTFA diet. Finally, all risk factors were comparable between the control and the moderate-rTFA diets.

CONCLUSIONS

These results suggest that, whereas a high dietary intake of TFA from ruminants may adversely affect cholesterol homeostasis, moderate intakes of rTFA that are well above the upper limit of current human consumption have neutral effects on plasma lipids and other cardiovascular disease risk factors.

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  • Authors+Show Affiliations

    ,

    Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada.

    , , , , , ,

    Source

    MeSH

    Adult
    Animal Feed
    Animals
    Butter
    Cardiovascular Diseases
    Cattle
    Cholesterol, HDL
    Cholesterol, LDL
    Cross-Over Studies
    Diet
    Dose-Response Relationship, Drug
    Double-Blind Method
    Female
    Humans
    Hydrogenation
    Male
    Milk
    Plant Oils
    Risk Factors
    Trans Fatty Acids

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18326596

    Citation

    Motard-Bélanger, Annie, et al. "Study of the Effect of Trans Fatty Acids From Ruminants On Blood Lipids and Other Risk Factors for Cardiovascular Disease." The American Journal of Clinical Nutrition, vol. 87, no. 3, 2008, pp. 593-9.
    Motard-Bélanger A, Charest A, Grenier G, et al. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am J Clin Nutr. 2008;87(3):593-9.
    Motard-Bélanger, A., Charest, A., Grenier, G., Paquin, P., Chouinard, Y., Lemieux, S., ... Lamarche, B. (2008). Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. The American Journal of Clinical Nutrition, 87(3), pp. 593-9.
    Motard-Bélanger A, et al. Study of the Effect of Trans Fatty Acids From Ruminants On Blood Lipids and Other Risk Factors for Cardiovascular Disease. Am J Clin Nutr. 2008;87(3):593-9. PubMed PMID: 18326596.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. AU - Motard-Bélanger,Annie, AU - Charest,Amélie, AU - Grenier,Geneviève, AU - Paquin,Paul, AU - Chouinard,Yvan, AU - Lemieux,Simone, AU - Couture,Patrick, AU - Lamarche,Benoît, PY - 2008/3/11/pubmed PY - 2008/4/16/medline PY - 2008/3/11/entrez SP - 593 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 3 N2 - BACKGROUND: The intake of trans fatty acids (TFA) from industrially hydrogenated vegetable oils (iTFA) is known to have a deleterious effect on cardiovascular health, the effects of TFA from ruminants (rTFA) are virtually unknown. OBJECTIVE: The purpose of the present study was to compare the effects of rTFA and iTFA on plasma LDL concentrations and other cardiovascular disease risk factors in healthy subjects. DESIGN: In a double-blind, randomized crossover controlled study, 38 healthy men were fed each of 4 experimental isoenergetic diets lasting 4 wk each. The 4 diets were high in rTFA (10.2 g/2500 kcal), moderate in rTFA (4.2 g/2500 kcal), high in iTFA (10.2 g/2500 kcal), and low in TFA from any source (2.2 g/2500 kcal) (control diet). RESULTS: Plasma LDL-cholesterol concentrations were significantly higher after the high- rTFA diet than after the control (P = 0.03) or the moderate- rTFA (P = 0.002) diet. Plasma LDL-cholesterol concentrations also were significantly (P = 0.02) higher after the iTFA diet than after the moderate-rTFA diet. Plasma HDL-cholesterol concentrations were significantly (P = 0.02) lower after the high-rTFA diet than after the moderate-rTFA diet. Finally, all risk factors were comparable between the control and the moderate-rTFA diets. CONCLUSIONS: These results suggest that, whereas a high dietary intake of TFA from ruminants may adversely affect cholesterol homeostasis, moderate intakes of rTFA that are well above the upper limit of current human consumption have neutral effects on plasma lipids and other cardiovascular disease risk factors. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18326596/Study_of_the_effect_of_trans_fatty_acids_from_ruminants_on_blood_lipids_and_other_risk_factors_for_cardiovascular_disease_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.3.593 DB - PRIME DP - Unbound Medicine ER -