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Antimicrobial susceptibility of periodontopathogenic bacteria.
J Antimicrob Chemother. 2008 May; 61(5):1087-91.JA

Abstract

OBJECTIVES

The aim of this study was to evaluate the resistance profiles of Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia/Prevotella nigrescens and to detect possible changes in antibiotic resistance over the time period of 1991-2005.

METHODS

A. actinomycetemcomitans (125 strains), P. gingivalis (152 strains) and P. intermedia/P. nigrescens (326 strains) isolated during the years 1991-2005 were tested for their susceptibility to amoxicillin/clavulanic acid, clindamycin, metronidazole, phenoxymethylpenicillin and tetracycline using the Etest.

RESULTS

No antibiotic resistance was detected in P. gingivalis, whereas a few isolates of P. intermedia were not susceptible to clindamycin (0.9%), phenoxymethylpenicillin (13.5%) or tetracycline (12.6%). Amoxicillin/clavulanic acid, tetracycline and metronidazole were the most effective antibiotics against A. actinomycetemcomitans with 0%, 0.8% and 20.8% non-susceptible isolates, respectively. However, 88% of the A. actinomycetemcomitans isolates were non-susceptible to phenoxymethylpenicillin and 88% to clindamycin. When strains isolated in the years 1991-94 were compared with those isolated in the years 2001-04, there was no statistically significant difference in the percentage of A. actinomycetemcomitans strains non-susceptible to clindamycin, metronidazole or phenoxymethylpenicillin, or in the percentage of P. intermedia strains non-susceptible to phenoxymethylpenicillin or tetracycline (P > 0.4 each).

CONCLUSIONS

Increasing antibiotic resistances in periodontopathogenic bacteria are not yet a problem in the Northern part of Switzerland.

Authors+Show Affiliations

Institute for Preventive Dentistry and Oral Microbiology, Dental School, University of Basel, Hebelstrasse 3, CH-4056 Basel, Switzerland. eva.kulik@unibas.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18326855

Citation

Kulik, Eva M., et al. "Antimicrobial Susceptibility of Periodontopathogenic Bacteria." The Journal of Antimicrobial Chemotherapy, vol. 61, no. 5, 2008, pp. 1087-91.
Kulik EM, Lenkeit K, Chenaux S, et al. Antimicrobial susceptibility of periodontopathogenic bacteria. J Antimicrob Chemother. 2008;61(5):1087-91.
Kulik, E. M., Lenkeit, K., Chenaux, S., & Meyer, J. (2008). Antimicrobial susceptibility of periodontopathogenic bacteria. The Journal of Antimicrobial Chemotherapy, 61(5), 1087-91. https://doi.org/10.1093/jac/dkn079
Kulik EM, et al. Antimicrobial Susceptibility of Periodontopathogenic Bacteria. J Antimicrob Chemother. 2008;61(5):1087-91. PubMed PMID: 18326855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility of periodontopathogenic bacteria. AU - Kulik,Eva M, AU - Lenkeit,Krystyna, AU - Chenaux,Stephan, AU - Meyer,Jürg, Y1 - 2008/03/07/ PY - 2008/3/11/pubmed PY - 2008/6/11/medline PY - 2008/3/11/entrez SP - 1087 EP - 91 JF - The Journal of antimicrobial chemotherapy JO - J. Antimicrob. Chemother. VL - 61 IS - 5 N2 - OBJECTIVES: The aim of this study was to evaluate the resistance profiles of Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia/Prevotella nigrescens and to detect possible changes in antibiotic resistance over the time period of 1991-2005. METHODS: A. actinomycetemcomitans (125 strains), P. gingivalis (152 strains) and P. intermedia/P. nigrescens (326 strains) isolated during the years 1991-2005 were tested for their susceptibility to amoxicillin/clavulanic acid, clindamycin, metronidazole, phenoxymethylpenicillin and tetracycline using the Etest. RESULTS: No antibiotic resistance was detected in P. gingivalis, whereas a few isolates of P. intermedia were not susceptible to clindamycin (0.9%), phenoxymethylpenicillin (13.5%) or tetracycline (12.6%). Amoxicillin/clavulanic acid, tetracycline and metronidazole were the most effective antibiotics against A. actinomycetemcomitans with 0%, 0.8% and 20.8% non-susceptible isolates, respectively. However, 88% of the A. actinomycetemcomitans isolates were non-susceptible to phenoxymethylpenicillin and 88% to clindamycin. When strains isolated in the years 1991-94 were compared with those isolated in the years 2001-04, there was no statistically significant difference in the percentage of A. actinomycetemcomitans strains non-susceptible to clindamycin, metronidazole or phenoxymethylpenicillin, or in the percentage of P. intermedia strains non-susceptible to phenoxymethylpenicillin or tetracycline (P > 0.4 each). CONCLUSIONS: Increasing antibiotic resistances in periodontopathogenic bacteria are not yet a problem in the Northern part of Switzerland. SN - 1460-2091 UR - https://www.unboundmedicine.com/medline/citation/18326855/Antimicrobial_susceptibility_of_periodontopathogenic_bacteria_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkn079 DB - PRIME DP - Unbound Medicine ER -