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Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma.
Saudi Med J. 2008 Mar; 29(3):384-7.SM

Abstract

OBJECTIVE

Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma

METHODS

The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.

RESULTS

A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.

CONCLUSION

The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.

Authors+Show Affiliations

Department of Ophthalmology, Isfahan University of Medical Science, Feiz Hospital, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18327364

Citation

Rismanchian, Akram, et al. "Efficacy of the Latanoprost Versus Timolol/dorzolamide Combination Therapy in Patients With Primary Open Angle Glaucoma." Saudi Medical Journal, vol. 29, no. 3, 2008, pp. 384-7.
Rismanchian A, Eslami F, Moeini H, et al. Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma. Saudi Med J. 2008;29(3):384-7.
Rismanchian, A., Eslami, F., Moeini, H., Attarzade, H., & Naderibeni, A. (2008). Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma. Saudi Medical Journal, 29(3), 384-7.
Rismanchian A, et al. Efficacy of the Latanoprost Versus Timolol/dorzolamide Combination Therapy in Patients With Primary Open Angle Glaucoma. Saudi Med J. 2008;29(3):384-7. PubMed PMID: 18327364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma. AU - Rismanchian,Akram, AU - Eslami,Fateme, AU - Moeini,Heidarali, AU - Attarzade,Hosein, AU - Naderibeni,Afsane, PY - 2008/3/11/pubmed PY - 2008/7/23/medline PY - 2008/3/11/entrez SP - 384 EP - 7 JF - Saudi medical journal JO - Saudi Med J VL - 29 IS - 3 N2 - OBJECTIVE: Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma METHODS: The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups. RESULTS: A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective. CONCLUSION: The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/18327364/Efficacy_of_the_latanoprost_versus_timolol/dorzolamide_combination_therapy_in_patients_with_primary_open_angle_glaucoma_ L2 - http://www.diseaseinfosearch.org/result/9163 DB - PRIME DP - Unbound Medicine ER -