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Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases.
Head Neck. 2008 Aug; 30(8):1012-9.HN

Abstract

BACKGROUND

Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm.

METHODS

A retrospective chart review between 1960 and 2000 was performed. Sixty-eight patients with head and neck extramedullary plasmacytomas were included.

RESULTS

The sinonasal tract was the most common site. Thirty-nine patients were treated with radiation, 8 with surgery, 14 with surgery and radiation, and 3 with chemoradiation. Median follow-up was 8 years. The 5-year local recurrence-free rate (LRFR) was 81%. There was a trend toward improved LRFR in patients treated primarily with radiation. Regional recurrence at 5 years was 5%. Multiple myeloma developed in 23% of patients. The 5-year survival was 76%.

CONCLUSIONS

Radiation is the treatment of choice with surgery reserved for large tumors and extensive bone destruction. Long-term follow-up is essential because local recurrence and disseminated disease can occur many years postdiagnosis.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18327783

Citation

Bachar, Gideon, et al. "Solitary Extramedullary Plasmacytoma of the Head and Neck--long-term Outcome Analysis of 68 Cases." Head & Neck, vol. 30, no. 8, 2008, pp. 1012-9.
Bachar G, Goldstein D, Brown D, et al. Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases. Head Neck. 2008;30(8):1012-9.
Bachar, G., Goldstein, D., Brown, D., Tsang, R., Lockwood, G., Perez-Ordonez, B., & Irish, J. (2008). Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases. Head & Neck, 30(8), 1012-9. https://doi.org/10.1002/hed.20821
Bachar G, et al. Solitary Extramedullary Plasmacytoma of the Head and Neck--long-term Outcome Analysis of 68 Cases. Head Neck. 2008;30(8):1012-9. PubMed PMID: 18327783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases. AU - Bachar,Gideon, AU - Goldstein,David, AU - Brown,Dale, AU - Tsang,Richard, AU - Lockwood,Gina, AU - Perez-Ordonez,Bayardo, AU - Irish,Jonathan, PY - 2008/3/11/pubmed PY - 2008/10/31/medline PY - 2008/3/11/entrez SP - 1012 EP - 9 JF - Head & neck JO - Head Neck VL - 30 IS - 8 N2 - BACKGROUND: Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm. METHODS: A retrospective chart review between 1960 and 2000 was performed. Sixty-eight patients with head and neck extramedullary plasmacytomas were included. RESULTS: The sinonasal tract was the most common site. Thirty-nine patients were treated with radiation, 8 with surgery, 14 with surgery and radiation, and 3 with chemoradiation. Median follow-up was 8 years. The 5-year local recurrence-free rate (LRFR) was 81%. There was a trend toward improved LRFR in patients treated primarily with radiation. Regional recurrence at 5 years was 5%. Multiple myeloma developed in 23% of patients. The 5-year survival was 76%. CONCLUSIONS: Radiation is the treatment of choice with surgery reserved for large tumors and extensive bone destruction. Long-term follow-up is essential because local recurrence and disseminated disease can occur many years postdiagnosis. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/18327783/Solitary_extramedullary_plasmacytoma_of_the_head_and_neck__long_term_outcome_analysis_of_68_cases_ L2 - https://doi.org/10.1002/hed.20821 DB - PRIME DP - Unbound Medicine ER -