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Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31).
Clin Biochem. 2008 May; 41(7-8):480-5.CB

Abstract

OBJECTIVE

To assess the association of high sensitivity C-Reactive Protein [hsCRP] and Tumour Necrosis Factor-alpha [TNF-alpha] with IMT in Asian Indians with different grades of glucose intolerance.

DESIGN AND METHODS

Subjects with normal glucose tolerance [NGT](n=150), impaired glucose tolerance [IGT] (n=150) and type 2 diabetes (DM) (n=150) were recruited from the Chennai Urban Rural Epidemiology Study [CURES], in south India. hsCRP was estimated by nephelometry and TNF-alpha by enzyme linked immunosorbent assay. Carotid IMT was assessed by high resolution B-mode ultrasonography.

RESULTS

hsCRP and TNF-alpha levels were higher in those with DM [p<0.001] and IGT [p<0.001] compared to NGT. In linear regression analysis, both hsCRP [p=0.003] and TNF-alpha [p=0.001] showed an association with IMT among NGT subjects even after adjusting for age and gender. Among IGT subjects, TNF-alpha was associated with IMT [p<0.001], while no association was observed either with hsCRP or TNF-alpha in diabetic subjects. In NGT subjects, mean IMT was highest in those with high values [III tertile] of both TNF-alpha and hsCRP [0.83+/-0.1 mm; p<0.001] followed by those with high TNF-alpha+low hsCRP [0.74+/-0.09 mm; p<0.001], high hsCRPlow TNF-alpha [0.67+/-0.09 mm; p<0.001], and lowest in those with both low TNF-alpha and hsCRP [I tertile] [0.63+/-0.05 mm.

CONCLUSION

We conclude that in Asian Indians 1. Levels of hsCRP and TNF-alpha increase with increasing severity of glucose intolerance 2. Both hsCRP and TNF-alpha are associated with IMT in NGT subjects while TNF-alpha alone is associated with IMT in IGT subjects 3. hsCRP and TNF-alpha have a cumulative effect on mean IMT values in NGT subjects.

Authors+Show Affiliations

Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18328265

Citation

Gokulakrishnan, Kuppan, et al. "Association of High Sensitivity C-reactive Protein (hsCRP) and Tumour Necrosis Factor-alpha (TNF-alpha) With Carotid Intimal Medial Thickness in Subjects With Different Grades of Glucose Intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31)." Clinical Biochemistry, vol. 41, no. 7-8, 2008, pp. 480-5.
Gokulakrishnan K, Deepa R, Mohan V. Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). Clin Biochem. 2008;41(7-8):480-5.
Gokulakrishnan, K., Deepa, R., & Mohan, V. (2008). Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). Clinical Biochemistry, 41(7-8), 480-5. https://doi.org/10.1016/j.clinbiochem.2008.01.030
Gokulakrishnan K, Deepa R, Mohan V. Association of High Sensitivity C-reactive Protein (hsCRP) and Tumour Necrosis Factor-alpha (TNF-alpha) With Carotid Intimal Medial Thickness in Subjects With Different Grades of Glucose Intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). Clin Biochem. 2008;41(7-8):480-5. PubMed PMID: 18328265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). AU - Gokulakrishnan,Kuppan, AU - Deepa,Raj, AU - Mohan,Viswanathan, Y1 - 2008/02/21/ PY - 2007/08/11/received PY - 2008/01/11/revised PY - 2008/01/31/accepted PY - 2008/3/11/pubmed PY - 2008/10/22/medline PY - 2008/3/11/entrez SP - 480 EP - 5 JF - Clinical biochemistry JO - Clin Biochem VL - 41 IS - 7-8 N2 - OBJECTIVE: To assess the association of high sensitivity C-Reactive Protein [hsCRP] and Tumour Necrosis Factor-alpha [TNF-alpha] with IMT in Asian Indians with different grades of glucose intolerance. DESIGN AND METHODS: Subjects with normal glucose tolerance [NGT](n=150), impaired glucose tolerance [IGT] (n=150) and type 2 diabetes (DM) (n=150) were recruited from the Chennai Urban Rural Epidemiology Study [CURES], in south India. hsCRP was estimated by nephelometry and TNF-alpha by enzyme linked immunosorbent assay. Carotid IMT was assessed by high resolution B-mode ultrasonography. RESULTS: hsCRP and TNF-alpha levels were higher in those with DM [p<0.001] and IGT [p<0.001] compared to NGT. In linear regression analysis, both hsCRP [p=0.003] and TNF-alpha [p=0.001] showed an association with IMT among NGT subjects even after adjusting for age and gender. Among IGT subjects, TNF-alpha was associated with IMT [p<0.001], while no association was observed either with hsCRP or TNF-alpha in diabetic subjects. In NGT subjects, mean IMT was highest in those with high values [III tertile] of both TNF-alpha and hsCRP [0.83+/-0.1 mm; p<0.001] followed by those with high TNF-alpha+low hsCRP [0.74+/-0.09 mm; p<0.001], high hsCRPlow TNF-alpha [0.67+/-0.09 mm; p<0.001], and lowest in those with both low TNF-alpha and hsCRP [I tertile] [0.63+/-0.05 mm. CONCLUSION: We conclude that in Asian Indians 1. Levels of hsCRP and TNF-alpha increase with increasing severity of glucose intolerance 2. Both hsCRP and TNF-alpha are associated with IMT in NGT subjects while TNF-alpha alone is associated with IMT in IGT subjects 3. hsCRP and TNF-alpha have a cumulative effect on mean IMT values in NGT subjects. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/18328265/Association_of_high_sensitivity_C_reactive_protein__hsCRP__and_tumour_necrosis_factor_alpha__TNF_alpha__with_carotid_intimal_medial_thickness_in_subjects_with_different_grades_of_glucose_intolerance__the_Chennai_Urban_Rural_Epidemiology_Study__CURES_31__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(08)00078-7 DB - PRIME DP - Unbound Medicine ER -