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Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men.
Metabolism. 2008 Apr; 57(4):569-76.M

Abstract

In the absence of significant research, we performed a prospective study to examine the association between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). The study cohort comprised a total of 8329 healthy men, with normal baseline kidney functions and no proteinuria, working in a semiconductor manufacturing company and its 13 affiliates. Alcohol intake was assessed with a self-reported questionnaire. Biochemical tests for liver and metabolic function and abdominal ultrasonography were done. Chronic kidney disease was defined as either the presence of proteinuria or a glomerular filtration rate (GFR) of <60 mL/min per 1.73 m(2). Cox proportional hazards model was used to estimate hazard ratios in the model for CKD. During 26717.1 person-years of follow-up, 324 men developed CKD. Nonalcoholic fatty liver disease was associated with the development of CKD (crude relative risk, 2.18; 95% confidence interval [CI], 1.75-2.71); and this relationship remained significant even after adjustment for age, GFR, triglyceride, and high-density lipoprotein cholesterol (adjusted relative risk [aRR], 1.55; 95% CI, 1.23-1.95). The association between NAFLD and incident CKD was evident in the NAFLD group with elevated serum gamma-glutamyltransferase (GGT) (aRR, 2.31; 95% CI, 1.53-3.50), even after adjustment for age, GFR, triglyceride, and high-density lipoprotein cholesterol, but not in the NAFLD group without elevated GGT (aRR, 1.09; 95% CI, 0.79-1.50) (P = .008 for interaction). To summarize, NAFLD with elevated GGT concentration was associated with an increased CKD risk among nondiabetic, nonhypertensive Korean men, irrespective of metabolic syndrome.

Authors+Show Affiliations

Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 110-746, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18328362

Citation

Chang, Yoosoo, et al. "Nonalcoholic Fatty Liver Disease Predicts Chronic Kidney Disease in Nonhypertensive and Nondiabetic Korean Men." Metabolism: Clinical and Experimental, vol. 57, no. 4, 2008, pp. 569-76.
Chang Y, Ryu S, Sung E, et al. Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men. Metabolism. 2008;57(4):569-76.
Chang, Y., Ryu, S., Sung, E., Woo, H. Y., Oh, E., Cha, K., Jung, E., & Kim, W. S. (2008). Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men. Metabolism: Clinical and Experimental, 57(4), 569-76. https://doi.org/10.1016/j.metabol.2007.11.022
Chang Y, et al. Nonalcoholic Fatty Liver Disease Predicts Chronic Kidney Disease in Nonhypertensive and Nondiabetic Korean Men. Metabolism. 2008;57(4):569-76. PubMed PMID: 18328362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men. AU - Chang,Yoosoo, AU - Ryu,Seungho, AU - Sung,Eunju, AU - Woo,Hee-Yeon, AU - Oh,Eunock, AU - Cha,Kyungsoo, AU - Jung,Eunmi, AU - Kim,Won Sool, PY - 2007/03/05/received PY - 2007/11/28/accepted PY - 2008/3/11/pubmed PY - 2008/4/16/medline PY - 2008/3/11/entrez SP - 569 EP - 76 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 4 N2 - In the absence of significant research, we performed a prospective study to examine the association between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). The study cohort comprised a total of 8329 healthy men, with normal baseline kidney functions and no proteinuria, working in a semiconductor manufacturing company and its 13 affiliates. Alcohol intake was assessed with a self-reported questionnaire. Biochemical tests for liver and metabolic function and abdominal ultrasonography were done. Chronic kidney disease was defined as either the presence of proteinuria or a glomerular filtration rate (GFR) of <60 mL/min per 1.73 m(2). Cox proportional hazards model was used to estimate hazard ratios in the model for CKD. During 26717.1 person-years of follow-up, 324 men developed CKD. Nonalcoholic fatty liver disease was associated with the development of CKD (crude relative risk, 2.18; 95% confidence interval [CI], 1.75-2.71); and this relationship remained significant even after adjustment for age, GFR, triglyceride, and high-density lipoprotein cholesterol (adjusted relative risk [aRR], 1.55; 95% CI, 1.23-1.95). The association between NAFLD and incident CKD was evident in the NAFLD group with elevated serum gamma-glutamyltransferase (GGT) (aRR, 2.31; 95% CI, 1.53-3.50), even after adjustment for age, GFR, triglyceride, and high-density lipoprotein cholesterol, but not in the NAFLD group without elevated GGT (aRR, 1.09; 95% CI, 0.79-1.50) (P = .008 for interaction). To summarize, NAFLD with elevated GGT concentration was associated with an increased CKD risk among nondiabetic, nonhypertensive Korean men, irrespective of metabolic syndrome. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18328362/Nonalcoholic_fatty_liver_disease_predicts_chronic_kidney_disease_in_nonhypertensive_and_nondiabetic_Korean_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00416-7 DB - PRIME DP - Unbound Medicine ER -