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The link between allergic rhinitis and chronic otitis media with effusion in atopic patients.
Otolaryngol Clin North Am. 2008 Apr; 41(2):311-23, vi.OC

Abstract

The significant incidence of atopy associated with otitis media with effusion (OME) has suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators indicates that the mucosa of the middle ear can respond to antigen in the same way as does the mucosa of the lower respiratory tract. Recent characterization of the mucosa and effusion from atopic patients with OME reveals a Th2 cytokine and cellular profiles consistent with an allergic response, supporting the role of allergy in OME. In addition, animal studies demonstrate that inhibiting characteristic allergy cytokines can prevent the production of middle ear effusion. As the understanding of allergy and its role in the inflammation of OME continues to deepen, this will introduce focused treatments of OME in the atopic population.

Authors+Show Affiliations

Section of Nasal and Sinus Disorders, Head and Neck Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, A71, Cleveland, OH 44195, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18328370

Citation

Luong, Amber, and Peter S. Roland. "The Link Between Allergic Rhinitis and Chronic Otitis Media With Effusion in Atopic Patients." Otolaryngologic Clinics of North America, vol. 41, no. 2, 2008, pp. 311-23, vi.
Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin North Am. 2008;41(2):311-23, vi.
Luong, A., & Roland, P. S. (2008). The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngologic Clinics of North America, 41(2), 311-23, vi. https://doi.org/10.1016/j.otc.2007.11.004
Luong A, Roland PS. The Link Between Allergic Rhinitis and Chronic Otitis Media With Effusion in Atopic Patients. Otolaryngol Clin North Am. 2008;41(2):311-23, vi. PubMed PMID: 18328370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. AU - Luong,Amber, AU - Roland,Peter S, PY - 2008/3/11/pubmed PY - 2008/5/14/medline PY - 2008/3/11/entrez SP - 311-23, vi JF - Otolaryngologic clinics of North America JO - Otolaryngol Clin North Am VL - 41 IS - 2 N2 - The significant incidence of atopy associated with otitis media with effusion (OME) has suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators indicates that the mucosa of the middle ear can respond to antigen in the same way as does the mucosa of the lower respiratory tract. Recent characterization of the mucosa and effusion from atopic patients with OME reveals a Th2 cytokine and cellular profiles consistent with an allergic response, supporting the role of allergy in OME. In addition, animal studies demonstrate that inhibiting characteristic allergy cytokines can prevent the production of middle ear effusion. As the understanding of allergy and its role in the inflammation of OME continues to deepen, this will introduce focused treatments of OME in the atopic population. SN - 0030-6665 UR - https://www.unboundmedicine.com/medline/citation/18328370/The_link_between_allergic_rhinitis_and_chronic_otitis_media_with_effusion_in_atopic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0030-6665(07)00208-3 DB - PRIME DP - Unbound Medicine ER -