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Lipid metabolism in liver of rat exposed to cadmium.
Food Chem Toxicol. 2008 May; 46(5):1786-92.FC

Abstract

We investigated the effect of exposition to cadmium (Cd, 15ppm for 8 weeks) through drinking water on liver lipid metabolism in adult male Wistar rats. As compared to metal non-exposed (control) rats, the serum triglycerides, cholesterol and LDL+VLDL cholesterol concentrations increased. This was associated to a decrease of lipoprotein lipase activity in post heparinic plasma. The VLDL secretion from liver was not modified. Cd treatment increased triglycerides and decreased esterified cholesterol contents in liver. The high triglyceride mass was related to the increased glycerol-3-phosphate acyltransferase mRNA expression. In addition, the liver fatty acids synthesis increased, as determined by an increment of fatty acid synthetase and isocitrate dehydrogenase activities, and [(14)C]-acetate incorporation into saponifiable lipid fraction. The relative percentage of palmitic acid (16:0) and total saturated fatty acids were increased compared with control. Hepatic glucose-6-phosphate dehydrogenase, malic dehydrogenase and cholesteryl ester hydrolase activities were unchanged. In liver, the Cd treatment decreased triglyceride and cholesterol in mitochondria, also increased triglyceride in cytosol, and cholesterol and phospholipid contents in nuclei, compared with control. In addition, an increase of nuclei phosphatidylcholine synthesis was observed. Cd exposure alters directly or indirectly the serum lipid content and liver lipid metabolism.

Authors+Show Affiliations

Department of Biochemistry and Biological Sciences, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, IMBIO-SL, CONICET, San Luis, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18329778

Citation

Larregle, Ethel V., et al. "Lipid Metabolism in Liver of Rat Exposed to Cadmium." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 5, 2008, pp. 1786-92.
Larregle EV, Varas SM, Oliveros LB, et al. Lipid metabolism in liver of rat exposed to cadmium. Food Chem Toxicol. 2008;46(5):1786-92.
Larregle, E. V., Varas, S. M., Oliveros, L. B., Martinez, L. D., Antón, R., Marchevsky, E., & Giménez, M. S. (2008). Lipid metabolism in liver of rat exposed to cadmium. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(5), 1786-92. https://doi.org/10.1016/j.fct.2008.01.018
Larregle EV, et al. Lipid Metabolism in Liver of Rat Exposed to Cadmium. Food Chem Toxicol. 2008;46(5):1786-92. PubMed PMID: 18329778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid metabolism in liver of rat exposed to cadmium. AU - Larregle,Ethel V, AU - Varas,Silvia M, AU - Oliveros,Liliana B, AU - Martinez,Luis D, AU - Antón,Rosa, AU - Marchevsky,Eduardo, AU - Giménez,María S, Y1 - 2008/01/18/ PY - 2006/06/21/received PY - 2007/12/12/revised PY - 2008/01/10/accepted PY - 2008/3/11/pubmed PY - 2008/6/6/medline PY - 2008/3/11/entrez SP - 1786 EP - 92 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 5 N2 - We investigated the effect of exposition to cadmium (Cd, 15ppm for 8 weeks) through drinking water on liver lipid metabolism in adult male Wistar rats. As compared to metal non-exposed (control) rats, the serum triglycerides, cholesterol and LDL+VLDL cholesterol concentrations increased. This was associated to a decrease of lipoprotein lipase activity in post heparinic plasma. The VLDL secretion from liver was not modified. Cd treatment increased triglycerides and decreased esterified cholesterol contents in liver. The high triglyceride mass was related to the increased glycerol-3-phosphate acyltransferase mRNA expression. In addition, the liver fatty acids synthesis increased, as determined by an increment of fatty acid synthetase and isocitrate dehydrogenase activities, and [(14)C]-acetate incorporation into saponifiable lipid fraction. The relative percentage of palmitic acid (16:0) and total saturated fatty acids were increased compared with control. Hepatic glucose-6-phosphate dehydrogenase, malic dehydrogenase and cholesteryl ester hydrolase activities were unchanged. In liver, the Cd treatment decreased triglyceride and cholesterol in mitochondria, also increased triglyceride in cytosol, and cholesterol and phospholipid contents in nuclei, compared with control. In addition, an increase of nuclei phosphatidylcholine synthesis was observed. Cd exposure alters directly or indirectly the serum lipid content and liver lipid metabolism. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18329778/Lipid_metabolism_in_liver_of_rat_exposed_to_cadmium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00029-X DB - PRIME DP - Unbound Medicine ER -