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[Determination of HPLC fingerprint of Qingfengtong capsule].
Zhongguo Zhong Yao Za Zhi. 2007 Dec; 32(23):2492-3.ZZ

Abstract

OBJECTIVE

To establish a fingerprint analysis method of Qingfengtong capsule by HPLC.

METHOD

The samples were extracted with 70% ethanol in an ultrasonic bath. The extracts were analyzed at 35 degrees C on a Diamonsil C18 column (4.6 mm x 250 mm, 5 microm) with 0.1 mol x L(-1) potassium dihydrogen phosphate water-solution as mobile phase A, and methanol as mobile phase B. The analysis followed a linear gradient elution program. Initial condition of the mobile phase was 10% B for 2 minutes; then changed to 90% B in 40 minutes. The flow rate was kept at 1.0 ml x min(-1) and the detector wavelength was 262 nm.

RESULT

The main peaks in fingerprint chromatogram of Qingfengtong capsules were separated fairly well. The results of method validation meet the requirements for the fingerprints.

CONCLUSION

The established method can be used for the quality control of Qingfengtong capsules.

Authors+Show Affiliations

Zhang YX
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yang H
No affiliation info available
Zhang QW
No affiliation info available
Yi H
No affiliation info available
Chen GP
No affiliation info available

MeSH

CapsulesChromatography, High Pressure LiquidDrug CombinationsDrugs, Chinese HerbalEpimediumPlants, MedicinalQuality ControlReproducibility of ResultsSalvia miltiorrhizaSinomenium

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18330240

Citation

Zhang, Yong-Xin, et al. "[Determination of HPLC Fingerprint of Qingfengtong Capsule]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 32, no. 23, 2007, pp. 2492-3.
Zhang YX, Yang H, Zhang QW, et al. [Determination of HPLC fingerprint of Qingfengtong capsule]. Zhongguo Zhong Yao Za Zhi. 2007;32(23):2492-3.
Zhang, Y. X., Yang, H., Zhang, Q. W., Yi, H., & Chen, G. P. (2007). [Determination of HPLC fingerprint of Qingfengtong capsule]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 32(23), 2492-3.
Zhang YX, et al. [Determination of HPLC Fingerprint of Qingfengtong Capsule]. Zhongguo Zhong Yao Za Zhi. 2007;32(23):2492-3. PubMed PMID: 18330240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of HPLC fingerprint of Qingfengtong capsule]. AU - Zhang,Yong-Xin, AU - Yang,Hua, AU - Zhang,Qi-Wei, AU - Yi,Hong, AU - Chen,Gui-Pin, PY - 2008/3/12/pubmed PY - 2009/4/3/medline PY - 2008/3/12/entrez SP - 2492 EP - 3 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 32 IS - 23 N2 - OBJECTIVE: To establish a fingerprint analysis method of Qingfengtong capsule by HPLC. METHOD: The samples were extracted with 70% ethanol in an ultrasonic bath. The extracts were analyzed at 35 degrees C on a Diamonsil C18 column (4.6 mm x 250 mm, 5 microm) with 0.1 mol x L(-1) potassium dihydrogen phosphate water-solution as mobile phase A, and methanol as mobile phase B. The analysis followed a linear gradient elution program. Initial condition of the mobile phase was 10% B for 2 minutes; then changed to 90% B in 40 minutes. The flow rate was kept at 1.0 ml x min(-1) and the detector wavelength was 262 nm. RESULT: The main peaks in fingerprint chromatogram of Qingfengtong capsules were separated fairly well. The results of method validation meet the requirements for the fingerprints. CONCLUSION: The established method can be used for the quality control of Qingfengtong capsules. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/18330240/[Determination_of_HPLC_fingerprint_of_Qingfengtong_capsule]_ DB - PRIME DP - Unbound Medicine ER -